{"id":"W2167527031","doi":"10.1167/iovs.15-17567","title":"Early Onset Ultrastructural and Functional Defects in RPE and Photoreceptors of a Stargardt-Like Macular Dystrophy (STGD3) Transgenic Mouse Model","year":2015,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Ultrastructure; Retina; Cell biology; Biology; Outer nuclear layer; Retinal degeneration; Photoreceptor cell; Retinal; Electroretinography; Retinal pigment epithelium; Genetically modified mouse; Transgene; Anatomy; Biochemistry; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002435371,0.0007024401,0.0004086876,0.0007507774,0.0002761713,0.0003043976,0.0002443253,0.0009876263,0.001385544],"category_scores_gemma":[0.0001324754,0.0003219901,0.0005304233,0.0002136287,0.0004210879,0.0004476949,0.0003295122,0.0007183295,0.0004351282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004230513,"about_ca_system_score_gemma":0.0002544716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006354786,"about_ca_topic_score_gemma":0.001057847,"domain_scores_codex":[0.9997744,0.00002134334,0.00002635658,0.00005912021,0.00007138614,0.00004746095],"domain_scores_gemma":[0.9997819,0.00001488389,0.00009354098,0.00001856323,0.0000256759,0.00006547986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003140609,0.00007509407,0.0008573449,0.00004704097,0.000008294035,0.0007583998,0.00003726396,0.00004106325,0.9970795,0.00008545438,0.00003512751,0.0006613461],"study_design_scores_gemma":[0.0001774884,0.003381558,0.08033987,0.00006435651,0.0001302811,0.01355899,0.0002671691,0.001906634,0.8960968,0.0004533587,0.003592619,0.00003085077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958366,0.0009234092,0.001725945,0.00009321106,0.00001814674,0.00005719038,0.0004650829,0.000119617,0.0007607581],"genre_scores_gemma":[0.9911675,0.0006974974,0.00283142,0.00008725218,0.000009283875,0.00009787943,0.0006623581,0.00004129382,0.004405453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001385544,"threshold_uncertainty_score":0.004635096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02444856132770293,"score_gpt":0.2756257501601376,"score_spread":0.2511771888324347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}