{"id":"W2167527031","doi":"10.1167/iovs.15-17567","title":"Early Onset Ultrastructural and Functional Defects in RPE and Photoreceptors of a Stargardt-Like Macular Dystrophy (STGD3) Transgenic Mouse Model","year":2015,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Ultrastructure; Retina; Cell biology; Biology; Outer nuclear layer; Retinal degeneration; Photoreceptor cell; Retinal; Electroretinography; Retinal pigment epithelium; Genetically modified mouse; Transgene; Anatomy; Biochemistry; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.000318834,0.0001768803,0.000183279,0.0001200206,0.00008024541,0.00002003779,0.0001374172,0.0001088441,0.000007124428],"category_scores_gemma":[0.0001481013,0.0001596788,0.0000297153,0.0002529323,0.00273724,0.00002739699,0.00009565739,0.0001056023,0.000001029125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002439788,"about_ca_system_score_gemma":0.0003936859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007267949,"about_ca_topic_score_gemma":0.000007721306,"domain_scores_codex":[0.998708,0.00008311802,0.0002025871,0.0004770123,0.0002371419,0.000292184],"domain_scores_gemma":[0.9994402,0.0000157779,0.00007973005,0.00009747517,0.0001236292,0.0002431654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001301536,0.00002127636,0.2303793,0.000007275614,0.00001004153,0.000003147641,0.0004947959,0.0001168638,0.7687888,0.00001556113,0.00001462408,0.00001815925],"study_design_scores_gemma":[0.0008065493,0.000799669,0.3028314,0.00001013419,0.000008924709,0.00005516559,0.000299655,0.0005301695,0.6927243,0.0017158,0.000006060031,0.000212212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994317,0.0001387418,0.00002262684,0.00002739531,0.00006746092,0.0001762587,0.00001703021,0.000004698407,0.0001140608],"genre_scores_gemma":[0.9982693,0.00001243677,0.001521164,0.00006085963,0.00001014166,0.00001503177,0.00002458596,0.000009348201,0.00007718841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07606448,"threshold_uncertainty_score":0.9999768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02444856132770293,"score_gpt":0.2756257501601376,"score_spread":0.2511771888324347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}