{"id":"W2167531745","doi":"10.1017/s1461145710001343","title":"Partial agonists in schizophrenia – why some work and others do not: insights from preclinical animal models","year":2010,"lang":"en","type":"article","venue":"The International Journal of Neuropsychopharmacology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"Aripiprazole; Catalepsy; Dopamine receptor D2; Partial agonist; Haloperidol; Antipsychotic; Pharmacology; Dopaminergic; Psychology; Schizophrenia (object-oriented programming); Nucleus accumbens; Neuroscience; Medicine; Dopamine; Agonist; Receptor; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002654974,0.0002191196,0.000288139,0.0002411598,0.00007390756,0.0001574963,0.001548194,0.0001098459,0.0002806792],"category_scores_gemma":[0.0002178597,0.0001624336,0.0001291317,0.0001772619,0.0004803782,0.0006374805,0.0001439857,0.001595704,0.00003046572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002662082,"about_ca_system_score_gemma":0.00008012473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001082995,"about_ca_topic_score_gemma":0.000007143366,"domain_scores_codex":[0.9974273,0.0004464494,0.0007973901,0.0004286121,0.0006433903,0.0002568698],"domain_scores_gemma":[0.9980865,0.0009703239,0.0004570391,0.0002056353,0.0001078248,0.0001726885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00532559,0.0002445669,0.001044531,9.503779e-7,0.00001981287,0.0006201612,0.0003190015,0.0001803607,0.9874755,0.001000933,0.0003797081,0.003388955],"study_design_scores_gemma":[0.02221701,0.00124606,0.111667,0.0001161696,0.0001865264,0.001868444,0.00003584977,0.002105017,0.817104,0.0213354,0.02117202,0.0009465264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980953,0.00005082578,0.00001828025,0.01141469,0.007266906,0.000199922,0.00001752729,0.00002035562,0.00005852847],"genre_scores_gemma":[0.985454,0.0001630563,0.0001283996,0.01318955,0.001005901,0.00001266229,3.246151e-7,0.00003396566,0.00001219777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1703715,"threshold_uncertainty_score":0.6932629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04760338170321639,"score_gpt":0.3509550857125179,"score_spread":0.3033517040093015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}