{"id":"W2167557320","doi":"10.2174/1871520614666140608150448","title":"Deoxypodophyllotoxin Isolated from Juniperus communis Induces Apoptosis in Breast Cancer Cells","year":2014,"lang":"en","type":"article","venue":"Anti-Cancer Agents in Medicinal Chemistry","topic":"Biological Activity of Diterpenoids and Biflavonoids","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Moncton","funders":"Canadian Institutes of Health Research","keywords":"Apoptosis; Cancer; Lignan; MAPK/ERK pathway; Natural product; Cancer cell; Breast cancer; Traditional medicine; Biology; Chemistry; Medicine; Biochemistry; Botany; Signal transduction; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005877246,0.0002539236,0.0001448571,0.0002317565,0.0001090844,0.0001199184,0.00007659275,0.0001257077,0.0005875561],"category_scores_gemma":[0.00006821712,0.0000551361,0.0001195085,0.000154318,0.0001005601,0.00008832001,0.0001099097,0.0003020773,0.000145964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001016692,"about_ca_system_score_gemma":0.0001195138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005915448,"about_ca_topic_score_gemma":0.001395267,"domain_scores_codex":[0.9999673,0.000003644965,0.000002343543,0.000005773366,0.000009426681,0.00001140968],"domain_scores_gemma":[0.999957,0.000008150795,0.00001204229,0.000006450996,0.000006038343,0.00001035803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009962849,0.00002806404,0.0003747406,0.00004301202,0.00000392082,0.00005532189,0.00001299187,0.00002307466,0.9973575,0.00001153581,0.0000153922,0.001974734],"study_design_scores_gemma":[0.00003583958,0.001114238,0.03832296,0.00001306759,0.0000323285,0.0004365634,0.00007480988,0.0002605731,0.957085,0.00003335669,0.002587869,0.00000337911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964657,0.001628317,0.0003179904,0.00003156682,0.00001078743,0.00001658193,0.0001278043,0.00001584374,0.001385409],"genre_scores_gemma":[0.9960995,0.001458551,0.0004263971,0.0000372711,0.00001608888,0.00001660298,0.0004793745,0.000003994685,0.001462284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005915448,"threshold_uncertainty_score":0.001965582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01656664435939113,"score_gpt":0.2774306142152526,"score_spread":0.2608639698558614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}