{"id":"W2167580934","doi":"10.1186/1744-8069-2-2","title":"Impaired Inflammatory Pain and Thermal Hyperalgesia in Mice Expressing Neuron-Specific Dominant Negative Mitogen Activated Protein Kinase Kinase (MEK)","year":2006,"lang":"en","type":"article","venue":"Molecular Pain","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Health Canada; National Institutes of Health","keywords":"Protein kinase A; Hyperalgesia; Mitogen-activated protein kinase; Kinase; MAPK/ERK pathway; Mitogen-activated protein kinase kinase; Medicine; Cancer research; Chemistry; Cell biology; Biology; Nociception; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002591679,0.001718834,0.0004557321,0.001218846,0.000309556,0.0004877481,0.0005739918,0.0008237605,0.004262163],"category_scores_gemma":[0.0002168651,0.0004980806,0.000548889,0.0003210595,0.0008039622,0.000505045,0.0003622491,0.001527436,0.0009132512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005097851,"about_ca_system_score_gemma":0.0003659544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007847452,"about_ca_topic_score_gemma":0.001297451,"domain_scores_codex":[0.9996632,0.00003331252,0.00005156612,0.00009662601,0.00008239504,0.00007294173],"domain_scores_gemma":[0.9993678,0.00006126479,0.0003087642,0.00004133422,0.00003843664,0.0001823228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002890727,0.00009595002,0.0001671048,0.00006004125,0.000009937062,0.00009308208,0.00001960398,0.00004934785,0.9984994,0.00011835,0.00003487098,0.0005632486],"study_design_scores_gemma":[0.0001898109,0.001763692,0.01825636,0.000085814,0.0001387942,0.002089512,0.0001208265,0.001363555,0.9733792,0.0002354554,0.002351712,0.00002535465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886814,0.001477517,0.005254048,0.0002560231,0.00007867418,0.00009742502,0.002113552,0.0003823756,0.001658975],"genre_scores_gemma":[0.9782137,0.001958578,0.008526888,0.0001674469,0.00003696709,0.0003035714,0.001959721,0.0002179757,0.008615186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004262163,"threshold_uncertainty_score":0.01425833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007568101337410472,"score_gpt":0.2124044163223737,"score_spread":0.2048363149849632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}