{"id":"W2167598880","doi":"10.1074/jbc.m114.627406","title":"Dimeric Quaternary Structure of Human Laforin","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Glycogen Storage Diseases and Myoclonus","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Thomas Jefferson University","keywords":"Lafora disease; Dual-specificity phosphatase; Progressive myoclonus epilepsy; Phosphatase; Biology; Biochemistry; Dephosphorylation; Phosphorylation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007981704,0.00009283244,0.0003362243,0.00001558106,0.00002037774,0.0000035029,0.0001114517,0.0001193038,0.0004862044],"category_scores_gemma":[0.0001347441,0.0000546066,0.0002004299,0.00005178242,0.00007764039,0.00001668355,0.00002861932,0.0002051019,0.000001337689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001846045,"about_ca_system_score_gemma":0.00002492362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003515491,"about_ca_topic_score_gemma":4.369327e-8,"domain_scores_codex":[0.9992951,0.00001700504,0.0003331658,0.00008602488,0.0001523451,0.0001164306],"domain_scores_gemma":[0.9992748,0.00002867283,0.000296078,0.0001220541,0.0001158939,0.0001624446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001817594,0.00009798273,0.02045982,0.00008581018,0.00005042399,0.0002622648,0.00001111151,0.000001632162,0.9775847,0.00001272569,0.0003393005,0.0009124209],"study_design_scores_gemma":[0.001607695,0.001234467,0.0290336,0.0001385126,0.000141123,0.002628689,0.00009279873,0.00001415984,0.9594514,0.0006373873,0.004880332,0.0001398536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986182,0.0004209866,0.00003463995,0.00008442139,0.00007497702,0.00002629403,0.000005988798,0.000006363608,0.0007281223],"genre_scores_gemma":[0.9989305,0.00003029764,0.0002857093,0.0001156426,0.0004637276,2.014421e-7,0.00001011619,0.000005242093,0.0001585373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01813336,"threshold_uncertainty_score":0.5323598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01804546548928864,"score_gpt":0.2785719735436182,"score_spread":0.2605265080543296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}