{"id":"W2167610854","doi":"10.1158/1541-7786.mcr-11-0531","title":"<i>In Situ</i> Analysis of Mutant EGFRs Prevalent in Glioblastoma Multiforme Reveals Aberrant Dimerization, Activation, and Differential Response to Anti-EGFR Targeted Therapy","year":2012,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; Toronto Western Hospital; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Proximity ligation assay; Cetuximab; Epidermal growth factor receptor; Mutant; Cancer research; Cell culture; EGFR inhibitors; Biology; Chemistry; Monoclonal antibody; Receptor; Molecular biology; Antibody; Biochemistry; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003348002,0.0002467753,0.0007413769,0.002836953,0.00008310726,0.00003721259,0.0002633929,0.0001705072,0.0004937854],"category_scores_gemma":[0.0008993302,0.0002216655,0.0001294023,0.005849694,0.0002183977,0.0001813732,0.0001864591,0.000610208,0.000008508696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007957642,"about_ca_system_score_gemma":0.0004737865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001952017,"about_ca_topic_score_gemma":0.0004294426,"domain_scores_codex":[0.9944994,0.001328638,0.0006866145,0.0005932117,0.001816799,0.001075355],"domain_scores_gemma":[0.9978722,0.0003304028,0.00009842365,0.0006695617,0.0005717184,0.0004576553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005941407,0.0004680264,0.1321133,0.0001535718,0.0003313623,0.0000453445,0.002676274,0.0002794264,0.8560764,0.00002446791,0.0001701612,0.00172024],"study_design_scores_gemma":[0.001845725,0.0003780599,0.4312998,0.0002359546,0.00004740153,0.000002472991,0.0001456343,0.0004394565,0.5647421,0.00001122229,0.0007042089,0.0001479834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921642,0.001637683,0.0005799579,0.003481197,0.00006877174,0.001947851,0.00004860071,0.00001723763,0.00005451945],"genre_scores_gemma":[0.9976716,0.001037844,0.0001428769,0.000294563,0.00006237702,0.0005301331,0.00002044505,0.00005942765,0.0001807561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2991865,"threshold_uncertainty_score":0.9039255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04354928422118057,"score_gpt":0.405791521814,"score_spread":0.3622422375928194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}