{"id":"W2167612600","doi":"10.1172/jci27352","title":"Intestinal ABCA1 directly contributes to HDL biogenesis in vivo","year":2006,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":513,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"ABCA1; Biogenesis; In vivo; Cholesterol; Reverse cholesterol transport; Biology; Chylomicron; Apolipoprotein B; Tangier disease; Endocrinology; Internal medicine; Chemistry; Lipoprotein; Cell biology; Biochemistry; Transporter; Medicine; Genetics; Very low-density lipoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000315907,0.0003333509,0.0004571481,0.0003511221,0.0001811225,0.0007928337,0.0001789026,0.0004407396,0.003312498],"category_scores_gemma":[0.0004499869,0.0003302412,0.0002644664,0.0001526693,0.0003026345,0.0003546758,0.0003851409,0.0009848295,0.001004697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003006215,"about_ca_system_score_gemma":0.0002041331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000448431,"about_ca_topic_score_gemma":0.0003432845,"domain_scores_codex":[0.9997498,0.00005899744,0.00001576529,0.000055878,0.00004941706,0.00007004703],"domain_scores_gemma":[0.9995498,0.0001050213,0.00008580338,0.00008133879,0.00004589506,0.0001321234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001094143,0.00007668859,0.001705724,0.00007962724,0.00001016876,0.0002111817,0.00002637061,0.00004265734,0.991658,0.0003452012,0.0002066284,0.004543476],"study_design_scores_gemma":[0.0004029876,0.001083796,0.0512669,0.00003876035,0.000160835,0.002640674,0.0001231867,0.002989585,0.9270414,0.0008175069,0.01341252,0.00002185187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860656,0.003998706,0.005096484,0.0009337959,0.00008563638,0.00003187078,0.0004664015,0.0002591841,0.003062214],"genre_scores_gemma":[0.9926646,0.001281948,0.001627197,0.0002357354,0.00006234679,0.00003851668,0.0006275538,0.0000699001,0.003392013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003312498,"threshold_uncertainty_score":0.0110814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05412170132786905,"score_gpt":0.3633503876367106,"score_spread":0.3092286863088416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}