{"id":"W2167612600","doi":"10.1172/jci27352","title":"Intestinal ABCA1 directly contributes to HDL biogenesis in vivo","year":2006,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":513,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"ABCA1; Biogenesis; In vivo; Cholesterol; Reverse cholesterol transport; Biology; Chylomicron; Apolipoprotein B; Tangier disease; Endocrinology; Internal medicine; Chemistry; Lipoprotein; Cell biology; Biochemistry; Transporter; Medicine; Genetics; Very low-density lipoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002047377,0.0001174366,0.0006506789,0.0002971085,0.00002291052,0.0000264025,0.00009665651,0.0001334475,0.00003305775],"category_scores_gemma":[0.003946397,0.00008981187,0.0002112376,0.0004318785,0.0001161403,0.0001310023,0.0000224493,0.0003613218,0.00001797675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004625857,"about_ca_system_score_gemma":0.0002294044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001516711,"about_ca_topic_score_gemma":0.00008929789,"domain_scores_codex":[0.9973925,0.0001691605,0.001808056,0.0001530229,0.0003068303,0.0001704701],"domain_scores_gemma":[0.9980984,0.0005364348,0.0005489453,0.0001343011,0.0003977422,0.0002842326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005456298,0.0003158051,0.9012428,0.00002942451,0.000036644,0.00006086582,0.00004735322,0.00007655388,0.06941327,0.0004644515,0.0139405,0.0138267],"study_design_scores_gemma":[0.002864046,0.0003924788,0.9292232,0.000469379,0.0001206123,0.00008387842,0.000020897,0.0001330126,0.02948685,0.00297961,0.03414045,0.00008559704],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872439,0.0003685158,0.0004289275,0.01045359,0.0008175583,0.0001580355,0.000003258463,0.00001376657,0.0005124318],"genre_scores_gemma":[0.9885581,0.00004470493,0.005244364,0.003589181,0.002137813,0.000003228243,0.00000377377,0.00001343538,0.0004053868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03992643,"threshold_uncertainty_score":0.4724491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05412170132786905,"score_gpt":0.3633503876367106,"score_spread":0.3092286863088416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}