{"id":"W2167613997","doi":"10.2147/ijn.s26891","title":"A novel polyethyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis","year":2012,"lang":"en","type":"article","venue":"International Journal of Nanomedicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute; McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Transfection; Capsid; Gene delivery; Small interfering RNA; Virus-like particle; Adeno-associated virus; Genetic enhancement; Virus; Cytotoxicity; Molecular biology; Western blot; Cell; In vitro; MTT assay; Cancer cell; Cell culture; Virology; Chemistry; Biology; Vector (molecular biology); Cancer; Gene; Recombinant DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002250268,0.0003727306,0.0002042187,0.0002166531,0.0001213183,0.0002091258,0.0002298902,0.0004032647,0.0004312864],"category_scores_gemma":[0.000156256,0.0001719304,0.0002294004,0.0001401606,0.0001356381,0.000241978,0.0001160902,0.0002942423,0.0002800497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002959399,"about_ca_system_score_gemma":0.0002253925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004173814,"about_ca_topic_score_gemma":0.0005764032,"domain_scores_codex":[0.9998821,0.00001986314,0.000008403577,0.00002900757,0.00004878099,0.00001180079],"domain_scores_gemma":[0.9999325,0.00001256295,0.00002045046,0.000003809216,0.0000184356,0.00001208713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001952575,0.00001777172,0.00004417122,0.00007947066,0.000005522658,0.00006163795,0.0000120369,0.0001577022,0.9973847,0.00004831645,0.00003938607,0.002129794],"study_design_scores_gemma":[0.00001557798,0.0003965718,0.0007952076,0.000007564081,0.00002312632,0.0003733865,0.000006984199,0.002087314,0.9926991,0.00002281538,0.003561936,0.00001052628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9099422,0.0103549,0.07505699,0.0002661302,0.0001092712,0.0003938483,0.0002721107,0.0002747137,0.003329781],"genre_scores_gemma":[0.9375073,0.003786878,0.05354311,0.000140477,0.00002775042,0.0001922609,0.0005156938,0.00004975094,0.004236819],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0004312864,"threshold_uncertainty_score":0.002147198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01588869255912337,"score_gpt":0.2984735762212549,"score_spread":0.2825848836621315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}