{"id":"W2167626370","doi":"10.15252/emmm.201404588","title":"Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation","year":2015,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Alberta Prion Research Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; Canada Foundation for Innovation; University of Alberta; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Recombinant DNA; Infectivity; Transgene; Chemistry; Linker; Prion protein; Biophysics; Biology; Disease; Allele; Immunology; Biochemistry; Internal medicine; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003414387,0.0001854726,0.0001611769,0.00006347997,0.00007493598,0.00001823564,0.00009387316,0.00008314497,0.00002220842],"category_scores_gemma":[0.001097795,0.0001601156,0.00006222491,0.0001188779,0.0001118344,0.00001082995,0.00008673468,0.00007542894,0.000004910828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002906964,"about_ca_system_score_gemma":0.0001318608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006070848,"about_ca_topic_score_gemma":0.000005693696,"domain_scores_codex":[0.9986874,0.0001348527,0.000228952,0.0004572226,0.0002770504,0.0002144803],"domain_scores_gemma":[0.9985536,0.000007912636,0.000102775,0.0004659132,0.0001692019,0.0007005537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002571228,0.0001683748,0.016144,0.0002665061,0.0002142211,0.0003190388,0.0003454426,0.0002126608,0.8920503,0.001427809,0.008886796,0.07739364],"study_design_scores_gemma":[0.03035414,0.01178648,0.3332327,0.001479336,0.00291026,0.0007645494,0.002822676,0.003249357,0.269279,0.0924858,0.2471892,0.004446493],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.951763,0.02279174,0.02221983,0.002307313,0.0001543182,0.0004493691,0.000005349727,0.00003560177,0.0002735289],"genre_scores_gemma":[0.9970379,0.00075981,0.0002270341,0.001298372,0.0002673861,0.00003722552,0.0002467655,0.00002300855,0.0001024776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6227713,"threshold_uncertainty_score":0.6529323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02133865300385267,"score_gpt":0.2755983544060969,"score_spread":0.2542597014022442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}