{"id":"W2167626370","doi":"10.15252/emmm.201404588","title":"Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation","year":2015,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Alberta Prion Research Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; Canada Foundation for Innovation; University of Alberta; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Recombinant DNA; Infectivity; Transgene; Chemistry; Linker; Prion protein; Biophysics; Biology; Disease; Allele; Immunology; Biochemistry; Internal medicine; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001321818,0.0002584939,0.0001567043,0.0001331296,0.00009192497,0.0003401573,0.0001506455,0.0003239398,0.001014796],"category_scores_gemma":[0.000228825,0.000143971,0.0001310762,0.00008394471,0.0003133463,0.0002336595,0.0002210681,0.0003498923,0.0001741591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001622527,"about_ca_system_score_gemma":0.0001363156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004205069,"about_ca_topic_score_gemma":0.0006776465,"domain_scores_codex":[0.9999008,0.00001679604,0.00001115874,0.0000252337,0.00001556248,0.00003028047],"domain_scores_gemma":[0.999768,0.00003668782,0.0000795372,0.00001658324,0.00001192376,0.00008740678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004373214,0.00005505058,0.001416577,0.00001195725,0.00001049196,0.00009617295,0.00001826612,0.00009348821,0.9969155,0.0000928708,0.00001878789,0.0008335714],"study_design_scores_gemma":[0.00006638245,0.002126426,0.1567882,0.00002587168,0.0001499274,0.002357075,0.000194622,0.003098855,0.8330658,0.00050596,0.001584128,0.00003671645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994797,0.000147476,0.0001277574,0.00001004664,0.00000204798,0.000001920012,0.00003629173,0.000007061783,0.0001877357],"genre_scores_gemma":[0.9995645,0.00007872659,0.00008570315,0.00001446228,0.000001304689,0.000001707713,0.0000373329,0.000005113448,0.0002111502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001014796,"threshold_uncertainty_score":0.003394842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02133865300385267,"score_gpt":0.2755983544060969,"score_spread":0.2542597014022442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}