{"id":"W2167632051","doi":"10.1093/jac/dks212","title":"Liposomal encapsulation of vancomycin improves killing of methicillin-resistant Staphylococcus aureus in a murine infection model","year":2012,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antimicrobial agents and applications","field":"Chemistry","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"Cedars-Sinai Medical Center","keywords":"Vancomycin; Staphylococcus aureus; Liposome; Methicillin-resistant Staphylococcus aureus; Microbiology; Antibiotics; Medicine; Staphylococcal infections; Micrococcaceae; Antibacterial agent; Chemistry; Biology; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004163936,0.0001985755,0.000505631,0.0002153787,0.00004699039,0.00001284435,0.0001901199,0.0001863482,0.00008920979],"category_scores_gemma":[0.00002673152,0.0001767856,0.0002662978,0.0002580229,0.00008683913,0.000282504,0.00002810071,0.0002699953,8.619832e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008317761,"about_ca_system_score_gemma":0.0001078833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000156406,"about_ca_topic_score_gemma":0.00001863187,"domain_scores_codex":[0.9982638,0.00002592785,0.00109248,0.0001362693,0.0002137583,0.0002677012],"domain_scores_gemma":[0.9981639,0.00005412573,0.001220175,0.0002005783,0.0002829324,0.00007830362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003365414,0.0007176104,0.0041396,0.0001891288,0.00008608533,7.113046e-7,0.0006879072,0.003777825,0.9880326,0.0001105899,0.0001901768,0.001731265],"study_design_scores_gemma":[0.001495625,0.00005483718,0.002441735,0.0002568921,0.00004721362,0.000004615348,0.00004104922,0.002106337,0.9925404,0.0001316289,0.0007109284,0.0001687448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99159,0.0001737434,0.007568252,0.0002159221,0.00009978103,0.0001039071,0.00002788268,0.000009970568,0.0002105368],"genre_scores_gemma":[0.9910589,0.0006320587,0.007851734,0.00009653555,0.0002550262,0.000001499235,0.000007225193,0.00003217062,0.00006484515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004507834,"threshold_uncertainty_score":0.7209107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585211474605205,"score_gpt":0.2653863168524203,"score_spread":0.2495342021063683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}