{"id":"W2167641210","doi":"10.1086/381449","title":"Nucleoside-Related Mitochondrial Toxicity among HIV-Infected Patients Receiving Antiretroviral Therapy: Insights from the Evaluation of Venous Lactic Acid and Peripheral Blood Mitochondrial DNA","year":2004,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"HIV Legal Network; AIDS Vancouver; St. Paul's Hospital; Providence Health Care","funders":"","keywords":"Mitochondrial toxicity; Mitochondrial DNA; Hyperlactatemia; Nucleoside; Medicine; Venous blood; Nuclear DNA; Toxicity; Discontinuation; Nucleoside analogue; Virology; Biology; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002944048,0.000190553,0.0002798332,0.0005213823,0.000180686,0.0004447647,0.0001130789,0.000263552,0.0005220529],"category_scores_gemma":[0.001634845,0.000102038,0.00008470815,0.0003912896,0.0001784516,0.000171003,0.0001770597,0.0002520529,0.00006959434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001366936,"about_ca_system_score_gemma":0.0001279087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004781641,"about_ca_topic_score_gemma":0.0008810318,"domain_scores_codex":[0.9997427,0.0001228185,0.00002284141,0.00003075815,0.0000527075,0.00002811423],"domain_scores_gemma":[0.999487,0.0001751371,0.0001694443,0.00002004785,0.00005267543,0.00009570627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001317183,0.0001778033,0.9336618,0.0001011261,0.00006759982,0.001677006,0.0003529912,0.0001237028,0.030381,0.00006841062,0.00008972054,0.03198172],"study_design_scores_gemma":[0.0000546292,0.003021861,0.9744173,0.00003538643,0.0001329113,0.008256501,0.0005064532,0.00109584,0.01156893,0.000124818,0.0007743622,0.00001098728],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978315,0.001469306,0.000253579,0.00004778214,0.000002206983,0.00001152646,0.00004092687,0.000003546645,0.0003394497],"genre_scores_gemma":[0.9990263,0.000459003,0.0003207162,0.00004449581,0.000008971953,0.000006129905,0.00006351183,0.000001201288,0.0000697919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005220529,"threshold_uncertainty_score":0.001746416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02745796517518097,"score_gpt":0.3286937054494809,"score_spread":0.3012357402742999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}