{"id":"W2167643402","doi":"10.1186/2191-219x-3-48","title":"Chronic AMPK activity dysregulation produces myocardial insulin resistance in the human Arg302Gln-PRKAG2 glycogen storage disease mouse model","year":2013,"lang":"en","type":"article","venue":"EJNMMI Research","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"University of Ottawa; Heart and Stroke Foundation of Canada","keywords":"Internal medicine; Endocrinology; Medicine; Insulin resistance; AMPK; Glycogen; Insulin; Glycogen synthase; Skeletal muscle; Glucose uptake; Genetically modified mouse; Cardiac function curve; Insulin receptor; Protein kinase A; Transgene; Kinase; Heart failure; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013553,0.0001789757,0.0001776466,0.0001074189,0.000284256,0.0001328862,0.0005522976,0.0001308381,0.00005623245],"category_scores_gemma":[0.0002258427,0.0001423495,0.00008205636,0.0002800638,0.0002361862,0.00002943136,0.0001672105,0.0003670751,0.00004696017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001078395,"about_ca_system_score_gemma":0.000341873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001446531,"about_ca_topic_score_gemma":0.0004953257,"domain_scores_codex":[0.9972757,0.0006482769,0.0001833388,0.0006052267,0.0006856507,0.0006018628],"domain_scores_gemma":[0.9986022,0.00003254295,0.00006037941,0.0009282031,0.0002294392,0.0001472189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003087504,0.0003036188,0.001547662,0.0001681764,0.00006591792,0.000005766776,0.0005400892,0.002039028,0.9395699,0.001018275,0.02014923,0.03428359],"study_design_scores_gemma":[0.004227711,0.0005692403,0.1698002,0.0001132946,0.00006028283,0.000001039122,0.0003344943,0.006334456,0.468096,0.00976048,0.3392483,0.001454402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9526612,0.04486879,0.00009209503,0.0004073274,0.0000606822,0.0009011473,0.00004388521,0.00001286084,0.0009520349],"genre_scores_gemma":[0.9917869,0.00308646,0.0000671622,0.00009754491,0.001050717,0.0005239553,0.00009938016,0.00003256987,0.003255319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4714738,"threshold_uncertainty_score":0.5804846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03951530025190845,"score_gpt":0.3341120176217486,"score_spread":0.2945967173698401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}