{"id":"W2167646022","doi":"10.1023/a:1015694802521","title":"Targeting Anti-Apoptotic Genes Upregulated by Androgen Withdrawal Using Antisense Oligonucleotides to Enhance Androgen- and Chemo-Sensitivity in Prostate Cancer","year":2002,"lang":"en","type":"review","venue":"Investigational New Drugs","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"Ministry of Education, India; Ministry of Earth Sciences","keywords":"Androgen; Clusterin; Prostate cancer; Cancer research; Tumor progression; Biology; Cancer; Prostate; Medicine; Apoptosis; Oncology; Internal medicine; Hormone; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004040832,0.0007677593,0.00110941,0.0009854147,0.000213419,0.0005017089,0.0007007822,0.0005216611,0.001452841],"category_scores_gemma":[0.0002203348,0.0002049238,0.0002785446,0.00110421,0.000302874,0.0005034009,0.0002227453,0.0009053611,0.000832357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005713173,"about_ca_system_score_gemma":0.0005227452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009222575,"about_ca_topic_score_gemma":0.002015774,"domain_scores_codex":[0.9999142,0.00001009555,0.0000111373,0.00001751074,0.0000359865,0.00001113898],"domain_scores_gemma":[0.9999073,0.00003374614,0.00001608509,0.000004108895,0.00002922881,0.000009569625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003890639,0.0002238376,0.0002954825,0.008210763,0.0001076002,0.0004439006,0.00006523456,0.0006872218,0.05499592,0.002359708,0.01435538,0.9178658],"study_design_scores_gemma":[0.0002171183,0.0006179611,0.002536494,0.0007463351,0.0003283258,0.002823382,0.00006266571,0.0004328291,0.04167795,0.0009357092,0.9495772,0.00004399633],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002739464,0.9929227,0.001278238,0.0002305199,0.0002901334,0.00003037359,0.00004538046,0.00004264454,0.002420516],"genre_scores_gemma":[0.008141014,0.9869285,0.001355131,0.0002371043,0.0001352511,0.00003645981,0.0001226604,0.000005648138,0.003038316],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001452841,"threshold_uncertainty_score":0.004860222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02925980522481499,"score_gpt":0.3327340060412377,"score_spread":0.3034742008164227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}