{"id":"W2167661193","doi":"10.1158/0008-5472.can-08-0041","title":"Development of a Preclinical Model of Spontaneous Human Melanoma Central Nervous System Metastasis","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"National Cancer Institute; National Institutes of Health","keywords":"Melanoma; Medicine; Brain metastasis; Metastasis; Pathology; Primary tumor; Cancer; Central nervous system; Cancer research; Parenchyma; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004227276,0.0006737033,0.0004454129,0.0004594414,0.0003080918,0.0003334812,0.0006960187,0.0006182914,0.002583161],"category_scores_gemma":[0.0002519738,0.000250868,0.0003710457,0.0001792704,0.0003037474,0.0002975914,0.0003249996,0.001793739,0.0007108925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004751373,"about_ca_system_score_gemma":0.0005322473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001454211,"about_ca_topic_score_gemma":0.002039537,"domain_scores_codex":[0.99978,0.00004127869,0.00001877657,0.00004520341,0.00006466412,0.00005001114],"domain_scores_gemma":[0.9997817,0.0000378507,0.00003504065,0.00003923401,0.00002852835,0.00007770061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003444189,0.001430995,0.000302972,0.00007028631,0.00001595925,0.0001555704,0.00004249827,0.0004403356,0.9939867,0.0006114078,0.0003052283,0.002293624],"study_design_scores_gemma":[0.0003880883,0.01615057,0.002403375,0.00003362661,0.00005191578,0.0008116536,0.0000424112,0.003788036,0.9689163,0.0003186922,0.007080664,0.0000148168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780467,0.001375183,0.01324124,0.0002612363,0.0002043568,0.001082417,0.001445261,0.0002735303,0.004069953],"genre_scores_gemma":[0.9686648,0.001775501,0.01469555,0.0001547597,0.00004581621,0.001741159,0.002921498,0.00005879872,0.009942025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002583161,"threshold_uncertainty_score":0.008641601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2827505677954827,"score_gpt":0.4475728157989098,"score_spread":0.1648222480034272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}