{"id":"W2167689282","doi":"10.1128/mcb.01595-12","title":"Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation","year":2013,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Heterotopic Ossification and Related Conditions","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Dental and Craniofacial Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; Novartis Institutes for BioMedical Research; Canadian Institutes of Health Research; National Institute for Health and Care Research; British Heart Foundation; Wellcome Trust; Howard Hughes Medical Institute","keywords":"BMPR2; Biology; Fibrodysplasia ossificans progressiva; Signal transduction; Cell biology; Bone morphogenetic protein; Receptor; Activin receptor; Receptor Protein-Tyrosine Kinases; Protein kinase domain; Mutant; Scaffold protein; Receptor tyrosine kinase; Genetics; Heterotopic ossification; Gene; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001825535,0.0005554702,0.0002744183,0.0002213896,0.0001239501,0.0005777591,0.0003338569,0.0004390196,0.001384089],"category_scores_gemma":[0.0002156653,0.0002375537,0.0002855661,0.0001169038,0.0004830415,0.0002546109,0.0003706778,0.0005655613,0.0006534916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003318277,"about_ca_system_score_gemma":0.0002434479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003528917,"about_ca_topic_score_gemma":0.0005406358,"domain_scores_codex":[0.9997063,0.00004449965,0.00004067571,0.00004391902,0.00008988655,0.00007471903],"domain_scores_gemma":[0.9997532,0.00004891244,0.00008277073,0.00004377455,0.0000179997,0.00005331568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004013049,0.000007559729,0.0001310686,0.000007515047,0.00000206255,0.0001042425,0.000005736305,0.0000418709,0.999323,0.0001517085,0.00001248275,0.000172709],"study_design_scores_gemma":[0.00003715207,0.0001668426,0.004267475,0.0000046429,0.00001442152,0.002794401,0.00004629752,0.001029614,0.9894672,0.0001397605,0.00202498,0.000007256496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956769,0.0003847995,0.002247898,0.00005959939,0.00001425998,0.00001848065,0.0002149501,0.00007488939,0.001308136],"genre_scores_gemma":[0.9966229,0.00018641,0.001420111,0.00002715225,0.000005311376,0.00002765769,0.0003873666,0.00002414911,0.001298746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001384089,"threshold_uncertainty_score":0.004630208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01294379720279787,"score_gpt":0.2589303130059287,"score_spread":0.2459865158031309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}