{"id":"W2167689282","doi":"10.1128/mcb.01595-12","title":"Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation","year":2013,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Heterotopic Ossification and Related Conditions","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Dental and Craniofacial Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; Novartis Institutes for BioMedical Research; Canadian Institutes of Health Research; National Institute for Health and Care Research; British Heart Foundation; Wellcome Trust; Howard Hughes Medical Institute","keywords":"BMPR2; Biology; Fibrodysplasia ossificans progressiva; Signal transduction; Cell biology; Bone morphogenetic protein; Receptor; Activin receptor; Receptor Protein-Tyrosine Kinases; Protein kinase domain; Mutant; Scaffold protein; Receptor tyrosine kinase; Genetics; Heterotopic ossification; Gene; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00004707873,0.0001141254,0.0001716701,0.00006259751,0.0001683221,0.00001326731,0.00004133448,0.0002311084,0.002601327],"category_scores_gemma":[0.0000805966,0.00009140606,0.0000417173,0.0001192367,0.000226001,0.00005994063,0.00002944121,0.000164058,0.0004274335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002516722,"about_ca_system_score_gemma":0.00007871418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002221911,"about_ca_topic_score_gemma":4.889845e-7,"domain_scores_codex":[0.99928,0.00008066839,0.0001732786,0.0002502659,0.00004963574,0.0001661528],"domain_scores_gemma":[0.9994749,0.00001233853,0.00006077208,0.0001644144,0.0001631388,0.000124466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000262203,0.00005963871,0.0001673683,0.000008677791,0.00007687953,0.000006800966,0.0001411309,2.770364e-7,0.981852,0.008028058,0.0006301861,0.009002759],"study_design_scores_gemma":[0.001619905,0.0008950761,0.0006610049,0.00005367098,0.00008064452,0.0000593426,0.0002254516,0.000131739,0.797294,0.0004673451,0.1982357,0.000276163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835768,0.0004464263,0.003009422,0.002682845,0.0003179185,0.0006426285,0.00002546139,0.00005473198,0.00924377],"genre_scores_gemma":[0.9955782,0.0001074842,0.0004607892,0.0008960862,0.00005226245,0.00004935105,0.0004512124,0.0000100174,0.002394578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1976055,"threshold_uncertainty_score":0.9983104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01294379720279787,"score_gpt":0.2589303130059287,"score_spread":0.2459865158031309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}