{"id":"W2167698400","doi":"10.1016/j.freeradbiomed.2012.01.006","title":"Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure","year":2012,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Liver Disease and Transplantation","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Saint-Luc","funders":"Canadian Institutes of Health Research","keywords":"Oxidative stress; Hyperammonemia; Xanthine oxidase; Internal medicine; Endocrinology; Pathogenesis; Reactive oxygen species; Chemistry; Antioxidant; Lipid peroxidation; Medicine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001522411,0.0006052491,0.0004064417,0.0005466562,0.0002881052,0.000251039,0.0001784485,0.0003253148,0.001266414],"category_scores_gemma":[0.000137527,0.0002325968,0.0002256899,0.0002334335,0.0006386154,0.000430955,0.000245974,0.0009053012,0.0001238673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002576549,"about_ca_system_score_gemma":0.000403517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001197835,"about_ca_topic_score_gemma":0.001548527,"domain_scores_codex":[0.9999281,0.00001223084,0.00000587813,0.00001054198,0.00001315255,0.00003017311],"domain_scores_gemma":[0.9997833,0.00001120567,0.00008608081,0.0000195624,0.00002601388,0.00007391037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01704612,0.0007878119,0.007848401,0.0001939682,0.00008329796,0.0008340285,0.0001306976,0.0002452811,0.9659382,0.0003546716,0.0002193749,0.006318163],"study_design_scores_gemma":[0.0007385844,0.009803133,0.1759171,0.00005171966,0.0003809895,0.001687455,0.0006870524,0.003299406,0.8044353,0.001584779,0.0013666,0.00004801642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984328,0.0005136629,0.0006512011,0.00009132307,0.00001959367,0.00001018367,0.00006215522,0.00002098168,0.0001980992],"genre_scores_gemma":[0.9987146,0.0004187156,0.0003100922,0.00002651685,0.00001175041,0.00001767553,0.00007812646,0.000004569611,0.0004179382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001266414,"threshold_uncertainty_score":0.004236579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0132326947116442,"score_gpt":0.2715005484664178,"score_spread":0.2582678537547736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}