{"id":"W2167749314","doi":"10.1158/0008-5472.can-07-5997","title":"Androgen Levels Increase by Intratumoral <i>De novo</i> Steroidogenesis during Progression of Castration-Resistant Prostate Cancer","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":739,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"National Cancer Institute","keywords":"Prostate cancer; Dihydrotestosterone; Androgen; Androgen receptor; LNCaP; Androgen deprivation therapy; Tumor progression; Internal medicine; Endocrinology; Cancer research; Cancer; Prostate; Medicine; Biology; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001134996,0.0003120328,0.0002047549,0.0003692721,0.0001214241,0.0004021985,0.0001355013,0.0001579297,0.0007778376],"category_scores_gemma":[0.00009486685,0.0001614368,0.0002400651,0.0002364961,0.0002048357,0.0001405435,0.0001107672,0.0004556784,0.0003165223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003515278,"about_ca_system_score_gemma":0.0002685681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001839641,"about_ca_topic_score_gemma":0.002145425,"domain_scores_codex":[0.9999073,0.00001294234,0.000005756675,0.00002007932,0.00003058725,0.00002339862],"domain_scores_gemma":[0.9999123,0.00001397106,0.00002497955,0.000009066001,0.000009799845,0.00002990225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001199723,0.00001800297,0.0003402028,0.00001522479,0.000003349926,0.00002855348,0.0000117957,0.00004837081,0.998522,0.00002617305,0.00002043658,0.0008459075],"study_design_scores_gemma":[0.00001003108,0.0005880647,0.02190515,0.000004033735,0.00001681047,0.0002920071,0.00003530442,0.0007619382,0.9748589,0.00003208311,0.001487306,0.000008385805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992213,0.003978672,0.001729026,0.00005251702,0.00002268054,0.00002358306,0.000399556,0.0001630756,0.001417779],"genre_scores_gemma":[0.9953014,0.001141922,0.001001512,0.00003293223,0.000009957241,0.0000150262,0.00066799,0.00002426351,0.001805023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001839641,"threshold_uncertainty_score":0.003657877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08711475349095844,"score_gpt":0.4118222421841693,"score_spread":0.3247074886932109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}