{"id":"W2167749314","doi":"10.1158/0008-5472.can-07-5997","title":"Androgen Levels Increase by Intratumoral <i>De novo</i> Steroidogenesis during Progression of Castration-Resistant Prostate Cancer","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":739,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"National Cancer Institute","keywords":"Prostate cancer; Dihydrotestosterone; Androgen; Androgen receptor; LNCaP; Androgen deprivation therapy; Tumor progression; Internal medicine; Endocrinology; Cancer research; Cancer; Prostate; Medicine; Biology; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006011658,0.0002297902,0.0004177061,0.0002756432,0.0004676146,0.00003627912,0.0002146065,0.0001214447,0.0004927691],"category_scores_gemma":[0.00007100811,0.0001794857,0.00009464131,0.0008509376,0.0006791263,0.0001805663,0.0001293531,0.0004983478,0.00001051287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009241637,"about_ca_system_score_gemma":0.002689094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00218264,"about_ca_topic_score_gemma":0.0002061956,"domain_scores_codex":[0.9965648,0.0002279616,0.0004050769,0.0005176776,0.001294488,0.0009899861],"domain_scores_gemma":[0.9981347,0.00007195588,0.00009889453,0.0003983988,0.0007841451,0.0005119398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004876041,0.0003280243,0.1028136,0.0006863094,0.0001458967,0.0006835712,0.001035855,0.000009480846,0.8818322,0.000006527819,0.003980074,0.003602368],"study_design_scores_gemma":[0.004582967,0.0006654491,0.04135608,0.0006589993,0.00004175754,0.0001258608,0.0002217818,0.00001955232,0.9504408,0.00001774404,0.001676506,0.0001924583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807967,0.01542784,0.000001638268,0.001339759,0.00005875536,0.001391718,0.0005796956,0.00004385736,0.0003600609],"genre_scores_gemma":[0.986662,0.006402055,0.0001071244,0.00004263664,0.0001999131,0.001080367,0.00006646533,0.00005810905,0.0053813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06860857,"threshold_uncertainty_score":0.7319213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08711475349095844,"score_gpt":0.4118222421841693,"score_spread":0.3247074886932109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}