{"id":"W2167784969","doi":"10.1038/icb.2015.80","title":"IL‐7 induces clathrin‐mediated endocytosis of CD127 and subsequent degradation by the proteasome in primary human CD8 T cells","year":2015,"lang":"en","type":"article","venue":"Immunology and Cell Biology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"","keywords":"Interleukin-7 receptor; Cell biology; Internalization; Endosome; Endocytosis; Clathrin; Biology; Receptor; T cell; Intracellular; Chemistry; Immune system; IL-2 receptor; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006904483,0.0002786014,0.0005281592,0.0001987456,0.0001964063,0.00001067105,0.0003057175,0.0006645531,0.0000645353],"category_scores_gemma":[0.00006507686,0.0002016328,0.00005462463,0.0001778745,0.001570906,0.0001105444,0.0001741141,0.0005714085,0.00003275778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005063161,"about_ca_system_score_gemma":0.0001114555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006191431,"about_ca_topic_score_gemma":0.00002604327,"domain_scores_codex":[0.9974163,0.001155902,0.0005558443,0.0003820194,0.000029387,0.0004606106],"domain_scores_gemma":[0.9988558,0.0004284471,0.0002932887,0.0003323521,0.00006792983,0.00002218202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008934347,0.0001927506,0.004264746,0.00001729242,0.0001467664,0.000002118596,0.0008995481,3.097074e-7,0.9877649,0.0004313636,0.0002022091,0.00518457],"study_design_scores_gemma":[0.004007105,0.001215781,0.01500768,0.00002328017,0.00003325481,0.00007650279,0.000831987,6.877923e-7,0.9547673,0.0004245962,0.02335836,0.0002534981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.930626,0.06755349,0.00001025551,0.0003075825,0.0003421611,0.0004792041,0.00005155031,0.00003165962,0.0005981112],"genre_scores_gemma":[0.9947057,0.003804051,0.00001992009,0.000199455,0.000009331145,0.00008762344,0.0002774519,0.00001714978,0.0008793653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06407966,"threshold_uncertainty_score":0.8222346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01680702294706994,"score_gpt":0.2324448281309945,"score_spread":0.2156378051839246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}