{"id":"W2167869727","doi":"10.1371/journal.pone.0008732","title":"Hypoxia Activates a Ca2+-Permeable Cation Conductance Sensitive to Carbon Monoxide and to GsMTx-4 in Human and Mouse Sickle Erythrocytes","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Center for Research Resources; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Deoxygenation; Biophysics; Chemistry; Intracellular; Carbon monoxide; Hemoglobin; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008158644,0.0001487431,0.0001345435,0.00009078456,0.00006343309,0.0001224349,0.0001401786,0.0002367738,0.0007153204],"category_scores_gemma":[0.0001058077,0.00007963381,0.0001473837,0.00007128184,0.0001623028,0.0001426353,0.000114788,0.0002002243,0.0001473962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001775559,"about_ca_system_score_gemma":0.00008352128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005468029,"about_ca_topic_score_gemma":0.0004244727,"domain_scores_codex":[0.9999249,0.000009765431,0.000008240729,0.00002058445,0.00001846388,0.00001803664],"domain_scores_gemma":[0.9999447,0.000009296304,0.00001997407,0.000006923643,0.000006030361,0.00001301268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001109462,0.000002705294,0.0001605424,0.00001281154,0.000002098194,0.00003997122,0.00001042997,0.00001734529,0.9993223,0.00002738761,0.00001210748,0.0002813911],"study_design_scores_gemma":[0.00001993246,0.0003119097,0.02219459,0.000003871191,0.0000153116,0.0006011094,0.00002389699,0.0007974299,0.9748697,0.00004554855,0.001112401,0.000004282624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971456,0.0007872164,0.001295961,0.00006446821,0.000007867562,0.000008454463,0.0002359776,0.00003888304,0.0004155573],"genre_scores_gemma":[0.997781,0.0003798128,0.0007987702,0.0000430777,0.000005504583,0.00001721486,0.0002417767,0.000006171829,0.0007268026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007153204,"threshold_uncertainty_score":0.002392948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03111568222685532,"score_gpt":0.2514792961480664,"score_spread":0.220363613921211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}