{"id":"W2167924385","doi":"10.1016/j.neurobiolaging.2015.07.020","title":"Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain","year":2015,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Mitochondrial DNA; Biology; Mitochondrion; PARP1; Genetics; Internal medicine; Endocrinology; Polymerase; Poly ADP ribose polymerase; Medicine; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003201374,0.0001392561,0.0004101251,0.0002507865,0.00002223257,0.000004308793,0.000274132,0.0001708611,0.00001021627],"category_scores_gemma":[0.0002832199,0.0001064588,0.000184127,0.0003804642,0.0001711456,0.000003430987,0.00007313996,0.0001188079,0.000003436321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004728971,"about_ca_system_score_gemma":0.00005422559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005613593,"about_ca_topic_score_gemma":0.00006641289,"domain_scores_codex":[0.9985703,0.0005234531,0.0003166333,0.0003159772,0.00007346349,0.000200191],"domain_scores_gemma":[0.9991919,0.0001261954,0.0001690552,0.0004025603,0.0000638839,0.0000463578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002607969,0.00006846706,0.006667051,0.00001597115,0.0001387197,0.000004517267,0.0003356966,0.0004039215,0.9900086,0.00009426522,0.001896859,0.0001051482],"study_design_scores_gemma":[0.002276113,0.0007445993,0.01325248,0.00001414333,0.0005613667,0.00001946888,0.0002478294,0.00009162678,0.9792179,0.0000786827,0.003273156,0.0002226108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979033,0.0003346792,0.0004535533,0.0002752512,0.0006394787,0.00021967,0.00002163026,0.000006547114,0.0001459054],"genre_scores_gemma":[0.9984044,0.00003276149,0.0005157426,0.0006129228,0.0001153,0.00001772966,0.0001242345,0.00001185679,0.0001650257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01079066,"threshold_uncertainty_score":0.4341266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01213623103683448,"score_gpt":0.2536090564172721,"score_spread":0.2414728253804376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}