{"id":"W2167925280","doi":"10.1093/carcin/bgt351","title":"A siRNA screen identifies RAD21 , EIF3H , CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation","year":2013,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"Association pour la Recherche sur le Cancer; AstraZeneca","keywords":"Amplicon; Biology; Gene knockdown; Clonogenic assay; Gene; RNA interference; Carcinogenesis; Cancer research; Cell growth; Cancer; Gene duplication; Genetics; Candidate gene; Cell; RNA; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001120354,0.0002021508,0.0001779195,0.00004769601,0.0001335414,0.00009512853,0.0000963667,0.0001083025,0.000004642581],"category_scores_gemma":[0.000005956212,0.0001438696,0.00002823613,0.00007358698,0.0001390789,0.00001566157,0.00005840592,0.00006718256,0.000001738642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001465349,"about_ca_system_score_gemma":0.00004101206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001237021,"about_ca_topic_score_gemma":0.001072026,"domain_scores_codex":[0.9991581,0.00006590444,0.0001615788,0.0003153197,0.0001054414,0.0001936534],"domain_scores_gemma":[0.9995514,0.00003410139,0.00007447613,0.0001875514,0.00006875397,0.00008371987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001131381,0.00003574022,0.2025406,0.0002333327,0.00007903935,0.000004872087,0.0007766467,0.00008791165,0.7908927,0.000224818,0.00005955356,0.004951625],"study_design_scores_gemma":[0.00131856,0.0001873782,0.7985011,0.00005806932,0.00008059121,0.00007017236,0.0006881639,0.0006836912,0.197863,0.0001649776,0.00006036627,0.0003238912],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964616,0.002296957,0.00005914409,0.0004681681,0.00005718297,0.0004337837,0.00005098994,0.000006753666,0.0001653684],"genre_scores_gemma":[0.9974136,0.002035297,0.00006821583,0.000184326,0.000062061,0.0000817669,0.00003137401,0.00002632759,0.00009702548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5959606,"threshold_uncertainty_score":0.5866833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003686552780515251,"score_gpt":0.1897122625531894,"score_spread":0.1860257097726741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}