{"id":"W2167925280","doi":"10.1093/carcin/bgt351","title":"A siRNA screen identifies RAD21 , EIF3H , CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation","year":2013,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"Association pour la Recherche sur le Cancer; AstraZeneca","keywords":"Amplicon; Biology; Gene knockdown; Clonogenic assay; Gene; RNA interference; Carcinogenesis; Cancer research; Cell growth; Cancer; Gene duplication; Genetics; Candidate gene; Cell; RNA; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001442079,0.0004396905,0.0004107501,0.0003890852,0.0002024732,0.0002985095,0.0002834488,0.0002892276,0.001626492],"category_scores_gemma":[0.0001200467,0.0001631228,0.0002812661,0.0002337254,0.0001638939,0.00008640451,0.0001597679,0.0002910605,0.0004719572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002787891,"about_ca_system_score_gemma":0.0002563298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007005372,"about_ca_topic_score_gemma":0.002152025,"domain_scores_codex":[0.9998457,0.00001092918,0.00001506601,0.00003834194,0.00006905745,0.00002091473],"domain_scores_gemma":[0.9998875,0.00003900684,0.00003146936,0.00001274839,0.00001334133,0.00001595605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003407612,0.000009992044,0.0003911063,0.00002219627,0.000007810057,0.00007224234,0.000005461489,0.00006239623,0.9980423,0.00002909985,0.00003474062,0.001288549],"study_design_scores_gemma":[0.00001598911,0.0001434228,0.006655016,0.000003125186,0.00005189282,0.0004457167,0.0000143524,0.0007417406,0.9894239,0.00001724389,0.002483056,0.000004483668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990521,0.001574297,0.004406484,0.00009525727,0.00003175995,0.00006388784,0.001197817,0.0002590366,0.00185057],"genre_scores_gemma":[0.9855156,0.001551213,0.006390923,0.00008980265,0.000009165593,0.0001133973,0.002567853,0.00006168433,0.003700456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001626492,"threshold_uncertainty_score":0.005441129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003686552780515251,"score_gpt":0.1897122625531894,"score_spread":0.1860257097726741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}