{"id":"W2167936725","doi":"10.1186/1750-1326-7-3","title":"Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk","year":2012,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Institute Pasteur De Lille; Vlaamse regering; Instituut Born-Bunge; Fonds Wetenschappelijk Onderzoek; Canadian Institutes of Health Research; Bijzonder Onderzoeksfonds UGent; Universiteit Antwerpen; Alzheimer Society; Wellcome Trust; Belgian Federal Science Policy Office; Institut National de la Santé et de la Recherche Médicale; Medical Research Council; Howard Hughes Medical Institute","keywords":"Clusterin; Single-nucleotide polymorphism; Genetics; Genome-wide association study; Genetic association; SNP; Biology; Locus (genetics); Exon; Gene; Bioinformatics; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001064253,0.0005995487,0.000614744,0.001480381,0.0005209958,0.0007030516,0.0004806982,0.0005605326,0.001811846],"category_scores_gemma":[0.002332385,0.0001698794,0.00104899,0.002103797,0.0005090711,0.0001768709,0.0003194282,0.0003873149,0.0001246849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005042573,"about_ca_system_score_gemma":0.0004007735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02019298,"about_ca_topic_score_gemma":0.02550183,"domain_scores_codex":[0.9990569,0.0002508803,0.00006452302,0.0004019377,0.0001334168,0.0000923668],"domain_scores_gemma":[0.9985051,0.0006619652,0.0004778912,0.0001258735,0.0001294522,0.00009962201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002467524,0.00004839939,0.9538051,0.0003667476,0.006742746,0.0007622769,0.0002374542,0.001675055,0.0142735,0.0001932593,0.0005235192,0.01890455],"study_design_scores_gemma":[0.00008007399,0.0001587827,0.9911063,0.00009396499,0.002678604,0.001140691,0.0001209361,0.001176379,0.001613134,0.0002879975,0.001525223,0.00001778054],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871316,0.009508219,0.001224251,0.0001508042,0.00002773551,0.00001340409,0.001396987,0.00004682285,0.0005000843],"genre_scores_gemma":[0.9979189,0.0008151268,0.0005194191,0.00004169687,0.00002408918,0.000006646263,0.0005594663,0.000007297236,0.0001074424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02019298,"threshold_uncertainty_score":0.04015088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01989329681504955,"score_gpt":0.2435660833957305,"score_spread":0.223672786580681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}