{"id":"W2167952434","doi":"10.1128/iai.00005-10","title":"Fine-Tuning Synthesis of<i>Yersinia pestis</i>LcrV from Runaway-Like Replication Balanced-Lethal Plasmid in a<i>Salmonella enterica</i>Serovar Typhimurium Vaccine Induces Protection against a Lethal<i>Y. pestis</i>Challenge in Mice","year":2010,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Yersinia bacterium, plague, ectoparasites research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Petroleum Technology Research Centre","keywords":"Biology; Plasmid; Yersinia pestis; Virology; Salmonella enterica; Microbiology; Salmonella; Virulence; Molecular biology; Gene; Genetics; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001344972,0.0004351373,0.0002302067,0.0001848395,0.00006477411,0.0002909465,0.0002049723,0.0002505976,0.0005543398],"category_scores_gemma":[0.0001102679,0.0001692753,0.0002508493,0.000132448,0.0001953455,0.0001439121,0.0001737735,0.0005403517,0.000260341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000246881,"about_ca_system_score_gemma":0.0001764528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003343557,"about_ca_topic_score_gemma":0.000546806,"domain_scores_codex":[0.999841,0.00002479594,0.00002187101,0.00004085817,0.0000285301,0.00004304208],"domain_scores_gemma":[0.999858,0.00001920406,0.00006208619,0.00001471899,0.00001042712,0.00003557773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004905978,0.00002223188,0.00004969644,0.00001126078,0.000002020886,0.000007104827,0.000003350141,0.00003414368,0.9994053,0.0000230293,0.00001029857,0.0003824391],"study_design_scores_gemma":[0.0000204126,0.0004319396,0.001241804,0.000003237263,0.00001446599,0.00006308046,0.000008114214,0.0005542255,0.9968153,0.00001163755,0.000832842,0.000002960154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955587,0.0003641532,0.002953826,0.00004927009,0.00001852392,0.00004713965,0.0002940494,0.0001306652,0.0005835263],"genre_scores_gemma":[0.9932514,0.0002826276,0.004187318,0.00004460165,0.000008093992,0.00006093375,0.0007022474,0.00005638768,0.001406588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005543398,"threshold_uncertainty_score":0.001854479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01408100955576868,"score_gpt":0.2622818516199552,"score_spread":0.2482008420641865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}