{"id":"W2168033476","doi":"10.1002/anie.201305434","title":"A Comparative CEST NMR Study of Slow Conformational Dynamics of Small GTPases Complexed with GTP and GTP Analogues","year":2013,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Advanced NMR Techniques and Applications","field":"Chemistry","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"GTP'; GTPase; Chemistry; RHEB; Conformational isomerism; Nuclear magnetic resonance spectroscopy; Computer science; Biophysics; Computational biology; Stereochemistry; Biochemistry; Biology; Organic chemistry; Phosphorylation; Molecule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003121688,0.000284003,0.0003167206,0.000326102,0.0003659291,0.0003318906,0.0003552139,0.0004058458,0.002310839],"category_scores_gemma":[0.0004501611,0.0001592231,0.0003068401,0.0004021638,0.0005620134,0.0003491977,0.0001922666,0.0005583924,0.0004222295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004323928,"about_ca_system_score_gemma":0.0002381442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002021804,"about_ca_topic_score_gemma":0.001386618,"domain_scores_codex":[0.999862,0.00001996621,0.000006068381,0.00001937027,0.00006368856,0.00002896568],"domain_scores_gemma":[0.9997188,0.00009963113,0.00003526698,0.00002543067,0.00008337856,0.00003736645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004244221,0.00004681079,0.0002414505,0.00009199005,0.00002328407,0.0002235315,0.0001312253,0.0002473626,0.9963701,0.000352074,0.0002684791,0.001579386],"study_design_scores_gemma":[0.00009131274,0.0007582714,0.02008006,0.00002446172,0.00005973189,0.0009903538,0.0002338533,0.004483856,0.9672975,0.0002177987,0.005711941,0.00005077203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890769,0.00110837,0.002584798,0.0001836587,0.00003678054,0.00002984903,0.0004624343,0.00008334518,0.0064339],"genre_scores_gemma":[0.9897648,0.001642216,0.002006164,0.0001613727,0.00004117784,0.00005055151,0.001001441,0.00004945372,0.005282723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002310839,"threshold_uncertainty_score":0.007730544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02715526494780523,"score_gpt":0.2823898135123875,"score_spread":0.2552345485645822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}