{"id":"W2168037804","doi":"10.2217/fmb.15.101","title":"Safety, Tolerability and Pharmacokinetics of AFN–1252 Administered as Immediate Release Tablets in Healthy Subjects","year":2015,"lang":"en","type":"article","venue":"Future Microbiology","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"MaRS","funders":"","keywords":"Tolerability; Dosing; Medicine; Pharmacokinetics; Cmax; Pharmacology; Placebo; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004492108,0.0002561207,0.0007928087,0.0001614286,0.00003086726,0.000005525421,0.0001366961,0.0003097485,0.00008907665],"category_scores_gemma":[0.0002993562,0.0002263227,0.00007072504,0.000304073,0.0003523449,0.00003979207,0.0001161267,0.0004073137,0.00002508543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001535091,"about_ca_system_score_gemma":0.0005281437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001277921,"about_ca_topic_score_gemma":0.0002342688,"domain_scores_codex":[0.9980768,0.0002015295,0.0006849866,0.0004786651,0.00007932506,0.0004787219],"domain_scores_gemma":[0.9987331,0.000129014,0.000231994,0.0003797469,0.0002248977,0.0003012352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02204974,0.000667761,0.06525919,0.0006963464,0.00008201569,0.000298236,0.001385199,0.00000762209,0.8893279,0.0001685306,0.01624597,0.003811528],"study_design_scores_gemma":[0.04205346,0.009404191,0.1194381,0.0006389683,0.0003402446,0.002015092,0.00209988,0.00005192601,0.1802125,0.0005267971,0.6418902,0.001328708],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988027,0.003543087,0.0000245652,0.005829984,0.0007928107,0.0006973444,0.0001746756,0.00003140067,0.0008791649],"genre_scores_gemma":[0.9952011,0.0006972731,0.001015739,0.002326817,0.0003815388,0.00001054987,0.0001588888,0.00002855968,0.0001795985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7091154,"threshold_uncertainty_score":0.9229171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01814124481453002,"score_gpt":0.3002479451854473,"score_spread":0.2821067003709173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}