{"id":"W2168045627","doi":"10.1073/pnas.0900891106","title":"Synthesis, characterization, and immunogenicity in mice of <i>Shigella sonnei</i> O-specific oligosaccharide-core-protein conjugates","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"National Institute of Child Health and Human Development; National Institutes of Health","keywords":"Shigella sonnei; Shigella dysenteriae; Immunogenicity; Conjugate; Diphtheria toxin; Shigellosis; Antibody; Conjugate vaccine; Chemistry; Oligosaccharide; Shiga toxin; Microbiology; Biology; Virology; Shigella; Biochemistry; Toxin; Escherichia coli; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008878793,0.00007994507,0.0001435821,0.0000756713,0.00008425784,0.00001143406,0.0004375738,0.00007002202,0.000002114276],"category_scores_gemma":[0.0006532905,0.00005910591,0.00003918072,0.000361096,0.0006257244,0.00002379054,0.0001346386,0.00008004257,1.340319e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008805469,"about_ca_system_score_gemma":0.00002808674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005673601,"about_ca_topic_score_gemma":1.802218e-7,"domain_scores_codex":[0.9989544,0.000008996378,0.0002811518,0.0002062871,0.0004206012,0.0001285691],"domain_scores_gemma":[0.9994112,0.00003839769,0.0002728102,0.000009900558,0.0002482115,0.00001952563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000373952,0.00003659991,0.006380982,0.0000323776,0.000009143681,2.701095e-9,0.00005506055,0.000002475452,0.9899398,0.003154325,0.00003986515,0.0003119402],"study_design_scores_gemma":[0.00009641005,0.00005450826,0.1375777,0.00006552091,0.000002413525,0.000001306591,0.00006355377,0.00004406487,0.859594,0.002283688,0.0001650941,0.00005178875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971272,0.0007723871,0.000001126574,0.001454846,0.000004038764,0.0001690927,0.00002196777,0.000001884684,0.0004474561],"genre_scores_gemma":[0.9985374,0.0008131715,0.0004781473,0.00009437216,0.00003049721,0.000009860652,3.707108e-7,0.000002352296,0.00003378979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1311967,"threshold_uncertainty_score":0.2410269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02759739998399454,"score_gpt":0.2849105574302635,"score_spread":0.257313157446269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}