{"id":"W2168053510","doi":"10.1128/aac.46.12.3776-3781.2002","title":"Pharmacokinetics and Efficacies of Liposomal and Conventional Formulations of Tobramycin after Intratracheal Administration in Rats with Pulmonary<i>Burkholderia cepacia</i>Infection","year":2002,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Hospital for Sick Children","keywords":"Tobramycin; Pharmacokinetics; Pharmacology; Medicine; Area under the curve; Lung; Aminoglycoside; Burkholderia; Antibacterial agent; Minimum inhibitory concentration; Antibiotics; Microbiology; Biology; Internal medicine; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000239688,0.0002239865,0.0003480169,0.0001089736,0.00007092735,0.0002885737,0.000168307,0.0003129477,0.0003689319],"category_scores_gemma":[0.0003590685,0.0001047807,0.0001175635,0.00009200854,0.0002874495,0.0003963879,0.00008678262,0.0005032893,0.0001806183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002988059,"about_ca_system_score_gemma":0.0001840762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000464229,"about_ca_topic_score_gemma":0.0005014949,"domain_scores_codex":[0.9998266,0.0000435152,0.00001116493,0.00003590143,0.00004571989,0.00003702796],"domain_scores_gemma":[0.9997508,0.00004926004,0.00009963051,0.00002683847,0.00003406469,0.00003936915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00208365,0.0002247746,0.0006056846,0.00005536752,0.00001744071,0.00003563838,0.00003483451,0.0003402827,0.9910492,0.00004744279,0.00004775624,0.005457854],"study_design_scores_gemma":[0.0001499286,0.01222999,0.0069557,0.00001124218,0.00005917776,0.0002109723,0.0000699493,0.002914436,0.976034,0.00004809485,0.001298006,0.00001842833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972379,0.0009704898,0.001361952,0.00004266457,0.00001346157,0.00001976612,0.0000736138,0.00003882279,0.0002413814],"genre_scores_gemma":[0.9969235,0.0008666572,0.001550532,0.00004130192,0.00001166671,0.00002866988,0.0001163191,0.00001357467,0.0004478179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000464229,"threshold_uncertainty_score":0.002168059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01483662772951633,"score_gpt":0.2624801252771416,"score_spread":0.2476434975476253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}