{"id":"W2168086696","doi":"10.1128/mcb.22.15.5319-5336.2002","title":"Oxygen-Dependent Ubiquitination and Degradation of Hypoxia-Inducible Factor Requires Nuclear-Cytoplasmic Trafficking of the von Hippel-Lindau Tumor Suppressor Protein","year":2002,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Biology; Ubiquitin; Suppressor; Cytoplasm; Hypoxia-inducible factors; Nuclear protein; Cell biology; Hypoxia (environmental); Tumor suppressor gene; F-box protein; Cancer research; Nuclear export signal; Nuclear transport; Cell nucleus; Transcription factor; Molecular biology; Oxygen; Ubiquitin ligase; Genetics; Gene; Carcinogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001055852,0.0001450408,0.0001202245,0.00005830794,0.0001676475,0.0002365913,0.0001151484,0.0001254866,0.0005103674],"category_scores_gemma":[0.00009391052,0.00006796299,0.0001214767,0.00005701395,0.0002061562,0.0002197086,0.0001640273,0.0001605761,0.0002169961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003080214,"about_ca_system_score_gemma":0.0002671859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007826348,"about_ca_topic_score_gemma":0.001373651,"domain_scores_codex":[0.9999343,0.000009774952,0.000005450479,0.00001597248,0.00001941065,0.00001496695],"domain_scores_gemma":[0.999944,0.000008698036,0.00002122416,0.000008395542,0.000006972784,0.00001078953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005857554,0.00001293261,0.0002574317,0.00002274817,0.000002079356,0.0000616944,0.0000155384,0.00004239418,0.9982212,0.0002026423,0.00001933874,0.0010835],"study_design_scores_gemma":[0.000008585306,0.0000972371,0.00730425,0.000003513819,0.000006122105,0.0005378661,0.00002899374,0.0008643051,0.988186,0.00009559802,0.002863924,0.000003549012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926528,0.002302978,0.003589106,0.000090728,0.0000109327,0.000009072536,0.00008494074,0.00004641053,0.001213128],"genre_scores_gemma":[0.9955318,0.001068164,0.00159801,0.00002394961,0.00000521044,0.000008884227,0.0002291543,0.000009236637,0.001525544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007826348,"threshold_uncertainty_score":0.002234876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01208826497200665,"score_gpt":0.2153417546942965,"score_spread":0.2032534897222898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}