{"id":"W2168086696","doi":"10.1128/mcb.22.15.5319-5336.2002","title":"Oxygen-Dependent Ubiquitination and Degradation of Hypoxia-Inducible Factor Requires Nuclear-Cytoplasmic Trafficking of the von Hippel-Lindau Tumor Suppressor Protein","year":2002,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Biology; Ubiquitin; Suppressor; Cytoplasm; Hypoxia-inducible factors; Nuclear protein; Cell biology; Hypoxia (environmental); Tumor suppressor gene; F-box protein; Cancer research; Nuclear export signal; Nuclear transport; Cell nucleus; Transcription factor; Molecular biology; Oxygen; Ubiquitin ligase; Genetics; Gene; Carcinogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001574932,0.0001848045,0.000254951,0.00006513374,0.000086197,0.00001547672,0.0001715346,0.0001987532,0.00003049327],"category_scores_gemma":[0.00009023358,0.0001517348,0.0001043925,0.00008443103,0.0002201872,0.000008539065,0.0001394007,0.0001096291,9.022874e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008699852,"about_ca_system_score_gemma":0.0000275589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004114943,"about_ca_topic_score_gemma":0.00001680125,"domain_scores_codex":[0.9987563,0.0001718834,0.0003196007,0.0003961921,0.000124343,0.0002316811],"domain_scores_gemma":[0.9992819,0.000009967384,0.0002330437,0.000327435,0.00008871195,0.00005889542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004661368,0.00005959859,0.0001998732,0.00006154642,0.00004526398,0.000001011762,0.0001322487,0.000007705827,0.9931871,0.0007271367,0.00002914328,0.005502793],"study_design_scores_gemma":[0.0007311777,0.0002508268,0.0007393559,0.00002685485,0.00004385038,0.00002247664,0.00008274001,0.0001920318,0.9924676,0.000128115,0.005148293,0.0001666946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923897,0.005842746,0.000813964,0.000119819,0.0002235703,0.0003926255,0.00005139413,0.000008479034,0.0001576562],"genre_scores_gemma":[0.9991118,0.0002193399,0.0001904476,0.00007840779,0.0001075406,0.00001643797,0.00004141413,0.00002542906,0.000209176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006722061,"threshold_uncertainty_score":0.6187565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01208826497200665,"score_gpt":0.2153417546942965,"score_spread":0.2032534897222898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}