{"id":"W2168088054","doi":"10.1016/j.lrr.2015.07.003","title":"A radiolabeled antibody targeting CD123+ leukemia stem cells – initial radioimmunotherapy studies in NOD/SCID mice engrafted with primary human AML","year":2015,"lang":"en","type":"article","venue":"Leukemia Research Reports","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children; University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research; CSL Limited","keywords":"Radioimmunotherapy; Interleukin-3 receptor; Nod; Medicine; Cancer research; Leukemia; Bone marrow; Stem cell; Monoclonal antibody; Spleen; Immunology; Antibody; Biology; Endocrinology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003361251,0.0004541694,0.0005937543,0.0003605627,0.0001859167,0.0002524073,0.0002866307,0.0003930666,0.0008892773],"category_scores_gemma":[0.0001022003,0.000191202,0.0002980857,0.0002164388,0.0003381606,0.0002595185,0.000153591,0.0008266797,0.0003700225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002810849,"about_ca_system_score_gemma":0.0002187199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009349608,"about_ca_topic_score_gemma":0.0007655837,"domain_scores_codex":[0.9998248,0.00003423746,0.00001670878,0.00004035244,0.00003335422,0.00005060104],"domain_scores_gemma":[0.9999021,0.00001882146,0.00002321212,0.00001419927,0.00001081588,0.0000307612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002194814,0.0001248097,0.00009048713,0.00002291895,0.000005033809,0.00002756713,0.00002067307,0.00008757225,0.9984199,0.00006299093,0.00002402103,0.000894563],"study_design_scores_gemma":[0.00003343174,0.00202635,0.001057154,0.000002220791,0.00002532408,0.0002017891,0.000009041401,0.0005421248,0.9953101,0.00002158163,0.0007677814,0.000003057265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945763,0.0009441829,0.002739405,0.00007723859,0.00001896933,0.0000972563,0.0002929102,0.0001149022,0.001138833],"genre_scores_gemma":[0.9911579,0.001167344,0.004156557,0.00005375778,0.00002069022,0.000111374,0.0006982739,0.00004826221,0.002585723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009349608,"threshold_uncertainty_score":0.002974927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1673720073511262,"score_gpt":0.463160429935388,"score_spread":0.2957884225842617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}