{"id":"W2168089814","doi":"10.1039/b410394g","title":"Direct intramolecular arylation of unactivated arenes: application to the synthesis of aporphine alkaloids","year":2004,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Traditional and Medicinal Uses of Annonaceae","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Aporphine; Intramolecular force; Chemistry; Yield (engineering); Catalysis; Combinatorial chemistry; Alkaloid; Benzazepines; Stereochemistry; Organic chemistry; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002274104,0.0004458861,0.0002001856,0.0001867553,0.000199272,0.0002164671,0.0004299831,0.0003378494,0.002703761],"category_scores_gemma":[0.0002250877,0.000150005,0.0002411962,0.0002238577,0.0002508895,0.0003378551,0.0003231449,0.0007405783,0.0008347454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000148559,"about_ca_system_score_gemma":0.0002437241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002936546,"about_ca_topic_score_gemma":0.0006835072,"domain_scores_codex":[0.999871,0.00001871968,0.00001111715,0.00003050618,0.00002829069,0.00004036123],"domain_scores_gemma":[0.9999127,0.00001768364,0.00002223612,0.00002008889,0.00001397638,0.00001328325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008156673,0.0000455519,0.00007429016,0.0001909497,0.00001307941,0.0002218263,0.00006800378,0.0002207032,0.9889853,0.0006998403,0.0001579107,0.009240985],"study_design_scores_gemma":[0.00001646238,0.0002896411,0.0003828714,0.000005557538,0.0000120896,0.000259804,0.00001380392,0.0003149105,0.9942696,0.00008915344,0.004337147,0.000008898063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9193702,0.005073077,0.043223,0.0003876069,0.0002113812,0.0002525977,0.0006716154,0.000439954,0.03037042],"genre_scores_gemma":[0.9802113,0.003205593,0.009358983,0.000104628,0.00003610337,0.00007377179,0.0002908937,0.00005271393,0.00666602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002703761,"threshold_uncertainty_score":0.009044945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130982618202458,"score_gpt":0.2519716371027062,"score_spread":0.2406618109206816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}