{"id":"W2168103670","doi":"10.1124/dmd.31.1.7","title":"Constitutive Androstane Receptor and Pregnane X Receptor Gene Expression in Human Liver: Interindividual Variability and Correlation with CYP2B6 mRNA Levels","year":2003,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Pregnane X receptor; Constitutive androstane receptor; CYP2B6; Biology; Cytochrome P450; Messenger RNA; Gene expression; Receptor; CYP3A4; Gene; Nuclear receptor; Endocrinology; Internal medicine; Molecular biology; Transcription factor; Genetics; Metabolism; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001098195,0.0003302033,0.0004213839,0.0001633494,0.0003881508,0.00006588471,0.00008035933,0.0002352318,0.0002867754],"category_scores_gemma":[0.00006552586,0.0002894205,0.00003261837,0.0001828981,0.0004910279,0.0003819228,0.00008936982,0.0004747545,0.000005135847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002884576,"about_ca_system_score_gemma":0.00005059416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002495144,"about_ca_topic_score_gemma":0.00001185748,"domain_scores_codex":[0.9975177,0.0009545098,0.0003968374,0.0005946537,0.0001742541,0.0003620339],"domain_scores_gemma":[0.9990547,0.0002139911,0.0001776479,0.0001519931,0.00009246811,0.0003092396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001071443,0.0006512126,0.04849874,0.0001752526,0.0001323302,0.00003183079,0.006648898,0.0001418313,0.9045042,0.01683453,0.0002692703,0.02104051],"study_design_scores_gemma":[0.01488545,0.0002419537,0.1836375,0.0002783608,0.0008454307,0.0002191812,0.0009209064,0.001207697,0.7472707,0.002779811,0.04635641,0.001356635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885206,0.007482363,0.0009832244,0.00009254701,0.0005346732,0.0007220023,0.0004371327,0.00003935643,0.0011881],"genre_scores_gemma":[0.9938841,0.003417376,0.001972465,0.0002528288,0.0001077902,0.00007116421,0.0001502742,0.00002211604,0.0001218486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1572334,"threshold_uncertainty_score":0.9999558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03922641977277825,"score_gpt":0.3361975998094348,"score_spread":0.2969711800366566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}