{"id":"W2168104151","doi":"10.1186/1471-2474-15-452","title":"The 'Switch’ study protocol: a randomised-controlled trial of switching to an alternative tumour-necrosis factor (TNF)-inhibitor drug or abatacept or rituximab in patients with rheumatoid arthritis who have failed an initial TNF-inhibitor drug","year":2014,"lang":"en","type":"article","venue":"BMC Musculoskeletal Disorders","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Arthritis Society","funders":"Versus Arthritis; National Institute for Health and Care Research; Bristol-Myers Squibb","keywords":"Medicine; Abatacept; Rituximab; Adalimumab; Golimumab; Etanercept; Rheumatoid arthritis; Infliximab; Internal medicine; TNF inhibitor; Oncology; Physical therapy; Disease; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002072799,0.0009310324,0.002328082,0.0005568651,0.0006526507,0.0003998001,0.0007026305,0.0001403031,0.0002421873],"category_scores_gemma":[0.002739648,0.0005324953,0.0005950953,0.0005500842,0.0003472156,0.001095647,0.0002139317,0.0007493534,0.00002292087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001423291,"about_ca_system_score_gemma":0.0006310066,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001673565,"about_ca_topic_score_gemma":0.0643946,"domain_scores_codex":[0.9910482,0.002395362,0.001923019,0.001239738,0.002135419,0.001258275],"domain_scores_gemma":[0.9953917,0.001502727,0.0007000939,0.001086988,0.0005198561,0.0007986124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8811393,0.01316711,0.02969079,0.0002038908,0.0004163363,0.0000156501,0.01101344,0.0000264846,0.0001215938,0.00002328626,0.0001496328,0.06403253],"study_design_scores_gemma":[0.9360131,0.02241462,0.02933121,0.001141145,0.00002683333,0.000002569487,0.00843952,0.0009887636,0.0003066983,0.0001027742,0.0004245296,0.0008082255],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8325135,0.00004493013,0.0002729236,0.000151947,0.0002324032,0.1664844,0.00005157047,0.0001122912,0.0001360621],"genre_scores_gemma":[0.9026374,0.000130065,0.0002762256,0.00004510354,0.0002623885,0.09630302,0.0000526035,0.0001707674,0.0001224683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07018138,"threshold_uncertainty_score":0.9997126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112195569043501,"score_gpt":0.2996407440323354,"score_spread":0.2885187883419004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}