{"id":"W2168118416","doi":"10.1126/scisignal.2001430","title":"Antigen Potency and Maximal Efficacy Reveal a Mechanism of Efficient T Cell Activation","year":2011,"lang":"en","type":"article","venue":"Science Signaling","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Biotechnology and Biological Sciences Research Council; Cancer Research UK; Wellcome Trust","keywords":"Potency; Antigen; Mechanism (biology); Chemistry; Cell biology; Biology; Immunology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000865169,0.0008521984,0.0007439918,0.0004060922,0.0002334646,0.001195231,0.0007315138,0.0008444304,0.001072457],"category_scores_gemma":[0.00190494,0.0003961951,0.0007163467,0.0002024066,0.0008835841,0.002036948,0.0005586956,0.0009740164,0.000488318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008862,"about_ca_system_score_gemma":0.0004116462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002787008,"about_ca_topic_score_gemma":0.0001142987,"domain_scores_codex":[0.9994053,0.0001484181,0.00004969274,0.0001195257,0.0001539597,0.0001232211],"domain_scores_gemma":[0.9991278,0.000462685,0.0001694105,0.0001053567,0.00007572,0.00005905268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003176654,0.0001638808,0.003345183,0.0003917336,0.00006612282,0.0002436331,0.00008781398,0.08759348,0.8452869,0.04609106,0.0002874414,0.01612502],"study_design_scores_gemma":[0.00005506723,0.0008228648,0.006506821,0.00004877854,0.0001135002,0.0006618529,0.00007183266,0.3647709,0.5899594,0.03376841,0.003155689,0.00006480973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.723672,0.005800348,0.2587027,0.0005042886,0.00006820074,0.0001449271,0.0002971972,0.0004412256,0.01036904],"genre_scores_gemma":[0.9937083,0.0007063885,0.004686886,0.00008186135,0.0000169414,0.00004830133,0.00005631938,0.0000193458,0.0006756434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001195231,"threshold_uncertainty_score":0.006429851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02014693581896248,"score_gpt":0.2215930136172073,"score_spread":0.2014460777982448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}