{"id":"W2168120533","doi":"10.1073/pnas.0508207103","title":"Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2α RNA-dependent protein kinase","year":2005,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"National Cancer Institute; Canadian Institutes of Health Research; Terry Fox Foundation; Cancer Research Society","keywords":"Protein kinase R; Phosphorylation; MAP2K7; Biology; Mitogen-activated protein kinase kinase; eIF2; Tyrosine phosphorylation; Phosphorylation cascade; Protein kinase A; Cyclin-dependent kinase 9; Cell biology; MAP kinase kinase kinase; EIF-2 kinase; Cyclin-dependent kinase 2; Protein phosphorylation; Biochemistry; Translation (biology); Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009605368,0.0002852005,0.0001229623,0.00009248178,0.0001552202,0.0002719935,0.0001068628,0.0001677561,0.002143777],"category_scores_gemma":[0.0000930057,0.0001161567,0.0001485915,0.00008334847,0.0001738489,0.0002152197,0.0002867368,0.0003207288,0.0006756313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002511997,"about_ca_system_score_gemma":0.0001461934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001866893,"about_ca_topic_score_gemma":0.0003520546,"domain_scores_codex":[0.9999233,0.000008644668,0.000004096843,0.00002150508,0.00001568258,0.00002674549],"domain_scores_gemma":[0.9999555,0.000004317313,0.0000109035,0.000005498574,0.000004207564,0.0000196839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001656256,0.00001900156,0.0002209482,0.00002759724,0.000003221443,0.00007774592,0.000007650098,0.00005985065,0.9969133,0.0002355315,0.0001107104,0.002158755],"study_design_scores_gemma":[0.00004681934,0.0002930029,0.009102431,0.000007744159,0.000008374104,0.0004610073,0.00003448349,0.0008776861,0.9824222,0.0002440681,0.006496318,0.000005900229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873967,0.003132528,0.004466728,0.0002366954,0.0001310383,0.00002511756,0.0002220236,0.0001365163,0.004252766],"genre_scores_gemma":[0.9939116,0.001070765,0.001120567,0.00005045754,0.00002412716,0.00001155612,0.0002631977,0.00001434465,0.0035333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002143777,"threshold_uncertainty_score":0.007171631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01391688834123284,"score_gpt":0.2759894783965283,"score_spread":0.2620725900552954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}