{"id":"W2168138547","doi":"10.1016/s0140-6736(07)61234-3","title":"Efficacy of sapropterin dihydrochloride (tetrahydrobiopterin, 6R-BH4) for reduction of phenylalanine concentration in patients with phenylketonuria: a phase III randomised placebo-controlled study","year":2007,"lang":"en","type":"article","venue":"The Lancet","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":311,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"Hospital for Sick Children; National Center for Research Resources; University of British Columbia; BioMarin Pharmaceutical; University of Minnesota","keywords":"Medicine; Tetrahydrobiopterin; Placebo; Phenylalanine; Phenylalanine hydroxylase; Internal medicine; Clinical endpoint; Gastroenterology; Randomized controlled trial; Chemistry; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000727918,0.0001479787,0.0005427208,0.00003397738,0.00003164672,0.000006987713,0.0001803733,0.00005431766,0.000009497297],"category_scores_gemma":[0.00009197198,0.00009801138,0.00007228262,0.00009839403,0.0000832635,0.000004794079,0.00002348147,0.00004955612,2.362991e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004163845,"about_ca_system_score_gemma":0.00002959177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002171402,"about_ca_topic_score_gemma":0.00003146232,"domain_scores_codex":[0.9988622,0.00007486293,0.000470949,0.000226225,0.0001426241,0.0002231431],"domain_scores_gemma":[0.9991916,0.00004186585,0.0002816957,0.0003631081,0.00009037981,0.00003133961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6517575,0.002122926,0.006943917,0.00005463667,0.0003224166,4.63004e-7,0.0009966491,0.0005461393,0.3327937,0.00002493662,0.0001324349,0.004304355],"study_design_scores_gemma":[0.803407,0.002390239,0.03014964,0.00003094081,0.0001854246,7.860055e-7,0.0003809679,0.0001272612,0.162702,0.00002083024,0.000400804,0.0002041595],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940051,0.0001464696,0.002109657,0.00002640808,0.0001332365,0.00329756,0.00002465535,0.000005461323,0.0002514737],"genre_scores_gemma":[0.9991947,0.00002786899,0.0002787035,0.00001930584,0.0002105208,0.0001032301,0.0001046069,0.00001410655,0.00004690439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1700917,"threshold_uncertainty_score":0.3996788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008454680790424328,"score_gpt":0.2630361742476963,"score_spread":0.254581493457272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}