{"id":"W2168138547","doi":"10.1016/s0140-6736(07)61234-3","title":"Efficacy of sapropterin dihydrochloride (tetrahydrobiopterin, 6R-BH4) for reduction of phenylalanine concentration in patients with phenylketonuria: a phase III randomised placebo-controlled study","year":2007,"lang":"en","type":"article","venue":"The Lancet","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":311,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"Hospital for Sick Children; National Center for Research Resources; University of British Columbia; BioMarin Pharmaceutical; University of Minnesota","keywords":"Medicine; Tetrahydrobiopterin; Placebo; Phenylalanine; Phenylalanine hydroxylase; Internal medicine; Clinical endpoint; Gastroenterology; Randomized controlled trial; Chemistry; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001987855,0.002819699,0.005754992,0.0007611329,0.0006499652,0.001385888,0.001673168,0.003686908,0.006959355],"category_scores_gemma":[0.001701283,0.001329918,0.002969841,0.0006621308,0.002704296,0.001605251,0.0004646923,0.004347638,0.001518559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001041885,"about_ca_system_score_gemma":0.001217358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002000511,"about_ca_topic_score_gemma":0.00254485,"domain_scores_codex":[0.9991078,0.0004104439,0.00006078265,0.0001562264,0.00006770165,0.0001971914],"domain_scores_gemma":[0.9988174,0.0003917377,0.0001786844,0.0001119837,0.00007675877,0.0004233857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9875479,0.003760919,0.0001578782,0.0002662151,0.0003938635,0.00003390043,0.00002476536,0.0001227218,0.002526019,0.00003293526,0.0002177859,0.004915124],"study_design_scores_gemma":[0.9450868,0.05340005,0.0007080684,0.00001001345,0.0002030888,0.00001453768,0.00001114656,0.0001217225,0.0002694143,0.00003832029,0.0001270616,0.000009759916],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898729,0.003896477,0.0006453223,0.0006014802,0.0005707645,0.001900583,0.0009287787,0.0001860305,0.001397657],"genre_scores_gemma":[0.988618,0.002995486,0.0009370451,0.0008686104,0.0006205808,0.001947865,0.001134286,0.00003925691,0.002838735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006959355,"threshold_uncertainty_score":0.02328134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008454680790424328,"score_gpt":0.2630361742476963,"score_spread":0.254581493457272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}