{"id":"W2168213980","doi":"10.1158/1535-7163.mct-14-0866","title":"Hsp27 Inhibition with OGX-427 Sensitizes Non–Small Cell Lung Cancer Cells to Erlotinib and Chemotherapy","year":2015,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"","keywords":"Erlotinib; A549 cell; Lung cancer; Medicine; Pharmacology; Hsp27; Cancer research; Cancer; Internal medicine; Biology; Epidermal growth factor receptor; Heat shock protein; Hsp70","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008605183,0.0003816739,0.0004346241,0.0002089901,0.0001597367,0.0002263038,0.0001562201,0.000226726,0.001667603],"category_scores_gemma":[0.00005355289,0.0001783235,0.0003450555,0.0002194289,0.0001740149,0.0001443174,0.0002128098,0.0005569434,0.0004028925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002163728,"about_ca_system_score_gemma":0.0002696691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001239396,"about_ca_topic_score_gemma":0.002660859,"domain_scores_codex":[0.999907,0.00001395262,0.000009781586,0.00001501893,0.00002320694,0.00003096893],"domain_scores_gemma":[0.9999627,0.000004682193,0.00000708171,0.000006702539,0.000005749175,0.00001312883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004173635,0.0002161483,0.0002168804,0.00009982081,0.00002645627,0.00008037536,0.00003212864,0.000350459,0.9940987,0.000087875,0.0003706688,0.004003194],"study_design_scores_gemma":[0.0001101034,0.002143574,0.007718979,0.00001192829,0.00003498486,0.000242095,0.00006329348,0.001454931,0.9832487,0.00004044887,0.004918116,0.00001290573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940013,0.001730171,0.0006918966,0.0001102465,0.0000540259,0.00007902423,0.0004354809,0.0001336427,0.002764255],"genre_scores_gemma":[0.9933728,0.001580995,0.000733897,0.00007483888,0.00000998222,0.00008031989,0.00107233,0.00002013491,0.003054763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001667603,"threshold_uncertainty_score":0.005578637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01952114444822322,"score_gpt":0.2950278219370564,"score_spread":0.2755066774888332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}