{"id":"W2168250718","doi":"10.1158/0008-5472.can-07-3217","title":"Vascular Endothelial Growth Factor–Mediated Decrease in Plasma Soluble Vascular Endothelial Growth Factor Receptor-2 Levels as a Surrogate Biomarker for Tumor Growth","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Toyota Research Institute, North America","keywords":"Angiogenesis; Vascular endothelial growth factor; Cancer research; Biomarker; In vivo; Receptor tyrosine kinase; Kinase insert domain receptor; Medicine; Cancer; Growth factor; Tumor progression; Vascular endothelial growth factor A; Receptor; Internal medicine; Biology; VEGF receptors; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009074385,0.0005587844,0.0006217562,0.0004081181,0.0004765443,0.00008395359,0.0008531717,0.0004417778,0.0009616144],"category_scores_gemma":[0.002374169,0.0005216945,0.0006253646,0.0006640195,0.0005308481,0.0000411743,0.0003333267,0.0004178314,0.0001044272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003697934,"about_ca_system_score_gemma":0.00195822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003934642,"about_ca_topic_score_gemma":0.0005330506,"domain_scores_codex":[0.9948456,0.0005084441,0.0006173075,0.001344735,0.001060067,0.001623805],"domain_scores_gemma":[0.9970297,0.0003550983,0.0001536216,0.0006697009,0.001124093,0.0006677552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001499668,0.0002975277,0.03843639,0.0001979994,0.0005166206,0.00006701425,0.0002943098,0.000006503322,0.9514731,0.000153305,0.006467561,0.0005899669],"study_design_scores_gemma":[0.006559971,0.0005901263,0.01486671,0.0001063933,0.0000342349,0.00002435134,0.00009872728,0.00008862946,0.9139587,0.000161829,0.06265733,0.0008529539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919964,0.003144852,0.0002522242,0.000242863,0.0005871721,0.001467165,0.001994851,0.00004768022,0.0002667688],"genre_scores_gemma":[0.9890684,0.006545925,0.0002559596,0.0002828233,0.0009833768,0.001394698,0.0003267394,0.0001860896,0.0009560126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05618977,"threshold_uncertainty_score":0.9999517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07211428138570343,"score_gpt":0.3388667513158498,"score_spread":0.2667524699301464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}