{"id":"W2168260860","doi":"10.1242/jcs.069997","title":"ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site","year":2010,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences","keywords":"Ectodomain; Biology; Cell biology; Signal transduction; Transmembrane domain; Cytoplasm; Transmembrane protein; Lysophosphatidic acid; Phosphorylation; Epidermal growth factor; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007956251,0.00008617632,0.0002414842,0.0003055958,0.0001281402,0.0001416908,0.0002260366,0.00004444195,0.0004020404],"category_scores_gemma":[0.0001407852,0.0000630603,0.0000768212,0.000600903,0.0001139296,0.0005893238,0.00006471074,0.0002313586,0.00002528708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003297819,"about_ca_system_score_gemma":0.0001786341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009752119,"about_ca_topic_score_gemma":0.000005511412,"domain_scores_codex":[0.9987823,0.00001248765,0.0002302969,0.0001727007,0.0005980099,0.000204196],"domain_scores_gemma":[0.998761,0.00003161255,0.0002297408,0.0001567949,0.0003346444,0.0004862135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003906514,0.00004116763,0.0001715743,0.00001171884,0.00000784631,0.00003174583,0.000155609,9.729005e-7,0.9901353,0.00001324711,0.009047912,0.0003438662],"study_design_scores_gemma":[0.001107652,0.0001887224,0.001141221,0.0001578634,0.00007542253,0.0002201861,0.00007012201,0.000939135,0.9925359,0.00008912857,0.003387684,0.00008690218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906378,0.00007916604,0.000389831,0.007121581,0.00007130453,0.0001055257,0.000008076822,0.000006807382,0.001579847],"genre_scores_gemma":[0.9934614,0.00004464702,0.0005310617,0.003305613,0.00005546581,5.560225e-7,8.297548e-7,0.000004637009,0.002595821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005660227,"threshold_uncertainty_score":0.4402061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01657140110043059,"score_gpt":0.280254874912029,"score_spread":0.2636834738115984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}