{"id":"W2168260860","doi":"10.1242/jcs.069997","title":"ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site","year":2010,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences","keywords":"Ectodomain; Biology; Cell biology; Signal transduction; Transmembrane domain; Cytoplasm; Transmembrane protein; Lysophosphatidic acid; Phosphorylation; Epidermal growth factor; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002642603,0.0003982068,0.0003913547,0.0002765426,0.0002059397,0.0004724014,0.0002151342,0.0002099053,0.001444281],"category_scores_gemma":[0.0002275279,0.0002341856,0.0003075017,0.0001795631,0.0004804733,0.0002606157,0.0002911127,0.0005791437,0.0005026885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002727801,"about_ca_system_score_gemma":0.0002504966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001571973,"about_ca_topic_score_gemma":0.0001535578,"domain_scores_codex":[0.9998028,0.00003233833,0.00001793183,0.00004228887,0.00006144174,0.00004328293],"domain_scores_gemma":[0.9997893,0.00002907236,0.00009477555,0.00003027049,0.00002490861,0.00003174341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000109504,0.00001129579,0.0003673225,0.00005339574,0.000008173023,0.0001771025,0.00002010545,0.00004464377,0.9947823,0.0003537436,0.00005224525,0.004020211],"study_design_scores_gemma":[0.00001779198,0.0001677048,0.004770468,0.0000083189,0.00001285057,0.001371676,0.00003460805,0.0002817284,0.987789,0.0001864579,0.005354275,0.000005250729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9670042,0.0104817,0.01917034,0.0001937395,0.00007647618,0.00009495484,0.0003565986,0.0002622975,0.002359685],"genre_scores_gemma":[0.9870182,0.004455669,0.005346654,0.00004244055,0.000038235,0.00007825936,0.0003318091,0.00003198812,0.002656788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001444281,"threshold_uncertainty_score":0.004831612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01657140110043059,"score_gpt":0.280254874912029,"score_spread":0.2636834738115984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}