{"id":"W2168279869","doi":"10.7150/jca.5956","title":"Synergistic Effect between Sphingosine-1-Phosphate and Chemotherapy Drugs against Human Brain-metastasized Breast Cancer MDA-MB-361 cells","year":2013,"lang":"en","type":"article","venue":"Journal of Cancer","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"College of Pharmacy and Nutrition, University of Saskatchewan; Cure Brain Cancer Foundation","keywords":"Sphingosine-1-phosphate; Docetaxel; Sphingosine; Angiogenesis; Pharmacology; Doxorubicin; Apoptosis; Cytotoxicity; Paclitaxel; Chemotherapy; Breast cancer; Cancer research; Cell growth; Cancer cell; Sphingolipid; Cyclophosphamide; Medicine; Cancer; MCF-7; Chemistry; Internal medicine; Receptor; Biochemistry; In vitro; Human breast","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000142849,0.0005312453,0.000751649,0.0004198432,0.0001800149,0.0002469563,0.000187828,0.0002210059,0.001245898],"category_scores_gemma":[0.0001175665,0.0001896084,0.0003188532,0.0002621231,0.0001419416,0.0001658853,0.0002652348,0.0004483282,0.0003009346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002179333,"about_ca_system_score_gemma":0.0004019048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001002216,"about_ca_topic_score_gemma":0.003642451,"domain_scores_codex":[0.9998598,0.0000411562,0.00001222856,0.0000192492,0.00003568732,0.00003189782],"domain_scores_gemma":[0.9999211,0.00002141241,0.00001148373,0.000007461397,0.000009724649,0.00002883768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002242451,0.0006538159,0.0007474564,0.0003744722,0.00008716781,0.0002462498,0.00008983537,0.0005185346,0.9803309,0.0001492894,0.0005972683,0.01396265],"study_design_scores_gemma":[0.0002088978,0.005346861,0.007878683,0.00002787595,0.0001934961,0.0005552257,0.00006249417,0.001100761,0.9785693,0.00004796807,0.005992908,0.00001550547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892578,0.007124703,0.0003784451,0.0001991894,0.00008158655,0.00006238426,0.0003303527,0.00004877897,0.002516795],"genre_scores_gemma":[0.992058,0.004628819,0.001131263,0.00007225328,0.00003566095,0.00006002582,0.0004324976,0.000007710706,0.001573755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001245898,"threshold_uncertainty_score":0.004167914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004795253529125158,"score_gpt":0.2663583363428865,"score_spread":0.2615630828137613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}