{"id":"W2168279869","doi":"10.7150/jca.5956","title":"Synergistic Effect between Sphingosine-1-Phosphate and Chemotherapy Drugs against Human Brain-metastasized Breast Cancer MDA-MB-361 cells","year":2013,"lang":"en","type":"article","venue":"Journal of Cancer","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"College of Pharmacy and Nutrition, University of Saskatchewan; Cure Brain Cancer Foundation","keywords":"Sphingosine-1-phosphate; Docetaxel; Sphingosine; Angiogenesis; Pharmacology; Doxorubicin; Apoptosis; Cytotoxicity; Paclitaxel; Chemotherapy; Breast cancer; Cancer research; Cell growth; Cancer cell; Sphingolipid; Cyclophosphamide; Medicine; Cancer; MCF-7; Chemistry; Internal medicine; Receptor; Biochemistry; In vitro; Human breast","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004973249,0.0002885594,0.0005493173,0.00008791032,0.0001338388,0.0001104492,0.0002583755,0.0001446417,0.0002222561],"category_scores_gemma":[0.0000336892,0.0002246705,0.0002069628,0.0001178029,0.0001064579,0.00002738013,0.00005889712,0.0002341884,0.000003488445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004178702,"about_ca_system_score_gemma":0.0001291492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003520507,"about_ca_topic_score_gemma":0.00001435229,"domain_scores_codex":[0.9984621,0.0001039437,0.0005097631,0.0002751907,0.0002877949,0.000361161],"domain_scores_gemma":[0.9987221,0.00006172529,0.0005023421,0.0002131635,0.0002547025,0.0002459229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000116703,0.00002319422,0.01180647,0.00005734402,0.0003588955,0.000004061483,0.0001037195,0.0001349073,0.9496723,0.000005441206,0.005995824,0.03172118],"study_design_scores_gemma":[0.005494484,0.0002225135,0.05521194,0.0002600787,0.0002493651,0.00001781184,0.00005130242,0.00004090301,0.890125,0.00005385817,0.04777455,0.0004981867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882415,0.009675651,0.0001770058,0.001039036,0.0005060948,0.0002103622,0.00005251393,0.000007919162,0.00008990948],"genre_scores_gemma":[0.9914325,0.003807543,0.0001786384,0.001602699,0.002536088,0.00002348976,0.000009601514,0.00005492969,0.0003545064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05954726,"threshold_uncertainty_score":0.9161796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004795253529125158,"score_gpt":0.2663583363428865,"score_spread":0.2615630828137613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}