{"id":"W2168288835","doi":"10.1093/hmg/ddl157","title":"Mapping genetic modulators of amyloid plaque deposition in TgCRND8 transgenic mice","year":2006,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Armand Frappier Museum","funders":"University of Toronto","keywords":"Biology; Quantitative trait locus; Genetics; Allele; Genetically modified mouse; Chromosome; Alzheimer's disease; Transgene; Genetic linkage; Chromosome 9; Gene; Internal medicine; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003190795,0.0009237098,0.0006714957,0.002057055,0.0004325566,0.0004317389,0.0006459875,0.0007169874,0.002367229],"category_scores_gemma":[0.0003047048,0.0005644824,0.0008197114,0.0007204916,0.0004362836,0.0001772504,0.0005870591,0.001042641,0.0005143079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006506342,"about_ca_system_score_gemma":0.0003857183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002355215,"about_ca_topic_score_gemma":0.003960914,"domain_scores_codex":[0.9994068,0.00007207825,0.00006614701,0.0002199495,0.0001326185,0.0001024198],"domain_scores_gemma":[0.9994674,0.0001267116,0.0002176674,0.00003566151,0.00004483658,0.0001077349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001843418,0.00008014308,0.000494597,0.00002781118,0.00001670038,0.00009663008,0.00003856596,0.0001145292,0.9979621,0.00006998408,0.00002703641,0.0008875435],"study_design_scores_gemma":[0.0004429934,0.001249476,0.07557286,0.00008419926,0.0004295827,0.002039115,0.0002257539,0.003982218,0.9080995,0.0003598054,0.007426875,0.00008771367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865303,0.0006162151,0.00868595,0.00009416607,0.00003077895,0.0001743274,0.002508527,0.0002483071,0.001111486],"genre_scores_gemma":[0.9489447,0.001622781,0.03252058,0.0001943097,0.00003191731,0.000662883,0.006027011,0.0003800661,0.009615673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002367229,"threshold_uncertainty_score":0.007919192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01499501937671457,"score_gpt":0.2741952909814293,"score_spread":0.2592002716047148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}