{"id":"W2168295595","doi":"10.1158/1078-0432.ccr-08-1688","title":"Improved Systemic Delivery of Oncolytic Reovirus to Established Tumors Using Preconditioning with Cyclophosphamide-Mediated Treg Modulation and Interleukin-2","year":2009,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"National Institutes of Health; National Cancer Institute; Richard M. Schulze Family Foundation; Mayo Foundation for Medical Education and Research","keywords":"Oncolytic virus; Medicine; Toxicity; Cyclophosphamide; Systemic administration; Pharmacology; Cancer research; Immunology; Chemotherapy; Internal medicine; In vivo; Immune system; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001613084,0.000656973,0.0003614327,0.0001569313,0.00008398506,0.0003162351,0.0002341115,0.0002576306,0.0008362214],"category_scores_gemma":[0.0001004779,0.0001106867,0.0002846493,0.00007634409,0.0002608929,0.0002856209,0.000184417,0.0006880042,0.0001704471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002235481,"about_ca_system_score_gemma":0.000224857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003396635,"about_ca_topic_score_gemma":0.0005312678,"domain_scores_codex":[0.9998628,0.00001687651,0.00001052731,0.00003865784,0.00002676979,0.00004439009],"domain_scores_gemma":[0.9999105,0.00001516583,0.00003273417,0.00001382585,0.000007116829,0.00002057018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000151596,0.00006368232,0.00004959754,0.00002814541,0.000003420638,0.00001349945,0.000006257897,0.00009617137,0.99847,0.00003939709,0.00001365248,0.001064479],"study_design_scores_gemma":[0.00005358389,0.00133163,0.000881054,0.000005124763,0.00001932692,0.0000794689,0.000005831653,0.0006740143,0.9963577,0.0000136941,0.0005756735,0.000002783582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944738,0.0008675458,0.003638353,0.00004829062,0.00003792211,0.00007561703,0.0001072628,0.00009344683,0.0006578676],"genre_scores_gemma":[0.9955307,0.0004900369,0.002933583,0.00003705735,0.00001683918,0.00005914861,0.0001430003,0.00001926029,0.000770485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008362214,"threshold_uncertainty_score":0.002797425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07224054727839395,"score_gpt":0.430337356991867,"score_spread":0.3580968097134731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}