{"id":"W2168295595","doi":"10.1158/1078-0432.ccr-08-1688","title":"Improved Systemic Delivery of Oncolytic Reovirus to Established Tumors Using Preconditioning with Cyclophosphamide-Mediated Treg Modulation and Interleukin-2","year":2009,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"National Institutes of Health; National Cancer Institute; Richard M. Schulze Family Foundation; Mayo Foundation for Medical Education and Research","keywords":"Oncolytic virus; Medicine; Toxicity; Cyclophosphamide; Systemic administration; Pharmacology; Cancer research; Immunology; Chemotherapy; Internal medicine; In vivo; Immune system; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002497939,0.0001582484,0.0003362069,0.0001967259,0.0001642496,0.00005696186,0.0002886119,0.0001844449,0.00002693477],"category_scores_gemma":[0.0006676655,0.0001407134,0.00006790805,0.0004966718,0.0002759177,0.00001819418,0.0001265719,0.0005203735,0.000003308957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000158594,"about_ca_system_score_gemma":0.0007902206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005033754,"about_ca_topic_score_gemma":0.000702486,"domain_scores_codex":[0.9972923,0.0006709753,0.0005772659,0.0005521272,0.000430898,0.0004764391],"domain_scores_gemma":[0.998225,0.0002523677,0.0001393142,0.0004559926,0.000646733,0.0002805939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01010742,0.0001384628,0.007378107,0.0000763351,0.00007861151,0.000006988299,0.0001229139,0.001266966,0.9427015,0.000002337662,0.0001327359,0.0379876],"study_design_scores_gemma":[0.008982454,0.05411754,0.092342,0.00170475,0.00007229828,0.00005608236,0.0009124691,0.01717691,0.8230074,0.0002668164,0.0003475327,0.001013766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977797,0.0008423395,0.0002728316,0.0001365758,0.00005493123,0.000774455,0.00003424079,0.00001289908,0.00009207129],"genre_scores_gemma":[0.9987196,0.0003333912,0.0003042924,0.0001674318,0.000210333,0.00006352601,0.00004251463,0.00003106998,0.0001278854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1196941,"threshold_uncertainty_score":0.5738127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07224054727839395,"score_gpt":0.430337356991867,"score_spread":0.3580968097134731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}