{"id":"W2168296515","doi":"10.1542/peds.2005-0975","title":"Tenofovir Disoproxil Fumarate and an Optimized Background Regimen of Antiretroviral Agents as Salvage Therapy for Pediatric HIV Infection","year":2005,"lang":"en","type":"article","venue":"PEDIATRICS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"National Institutes of Health","keywords":"Medicine; Salvage therapy; Regimen; Internal medicine; Dosing; Tolerability; Viral load; Enfuvirtide; Gastroenterology; Human immunodeficiency virus (HIV); Virology; Adverse effect; Immunology; Chemotherapy; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002891846,0.0004720195,0.0009662441,0.0001938624,0.0001500859,0.0002304476,0.0003304408,0.0002290038,0.0009749148],"category_scores_gemma":[0.0006415821,0.0001232591,0.0001899018,0.0002085319,0.0001876886,0.0002440736,0.000142293,0.0005234111,0.000116667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000245726,"about_ca_system_score_gemma":0.0003270126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000362829,"about_ca_topic_score_gemma":0.0009424382,"domain_scores_codex":[0.9997838,0.00008564498,0.0000209721,0.00004307034,0.00003273632,0.0000337838],"domain_scores_gemma":[0.9997436,0.00005081473,0.00007989378,0.00001722477,0.00001450943,0.00009389454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1539814,0.01337123,0.09838447,0.001345323,0.001201894,0.001455648,0.000362657,0.003920789,0.06566329,0.0004333604,0.002453698,0.6574263],"study_design_scores_gemma":[0.06589801,0.5121003,0.3191227,0.0005869099,0.001865556,0.01364546,0.0003343388,0.00711325,0.05721986,0.0004750028,0.02157875,0.00005991822],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993077,0.005717785,0.0003882458,0.00004897229,0.00001909014,0.0001017467,0.0000809026,0.00002926674,0.0005369636],"genre_scores_gemma":[0.9954305,0.001962175,0.001985298,0.00005794312,0.00005105928,0.0001082675,0.0002187272,0.00000518662,0.0001807942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009749148,"threshold_uncertainty_score":0.003261447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02531562710539356,"score_gpt":0.3100084937258335,"score_spread":0.28469286662044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}