{"id":"W2168296515","doi":"10.1542/peds.2005-0975","title":"Tenofovir Disoproxil Fumarate and an Optimized Background Regimen of Antiretroviral Agents as Salvage Therapy for Pediatric HIV Infection","year":2005,"lang":"en","type":"article","venue":"PEDIATRICS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"National Institutes of Health","keywords":"Medicine; Salvage therapy; Regimen; Internal medicine; Dosing; Tolerability; Viral load; Enfuvirtide; Gastroenterology; Human immunodeficiency virus (HIV); Virology; Adverse effect; Immunology; Chemotherapy; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003138862,0.0002567538,0.0004119092,0.0003252849,0.0001225182,0.00003517669,0.00006796961,0.0001378609,0.00006756932],"category_scores_gemma":[0.00005129747,0.0002118808,0.0001168877,0.0003831891,0.00004040463,0.0002877811,0.00003503772,0.0001170273,0.00003846124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009668815,"about_ca_system_score_gemma":0.0001567608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002722836,"about_ca_topic_score_gemma":0.000004055498,"domain_scores_codex":[0.9985431,0.00004648985,0.0004075996,0.0003762381,0.0003013321,0.0003252387],"domain_scores_gemma":[0.9991131,0.0000957957,0.0002177025,0.0002508907,0.0001278517,0.0001945873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001334454,0.001289217,0.9663421,0.000259955,0.0001342802,0.00001656543,0.001026338,0.00003204927,0.0001847168,0.0001306261,0.0109661,0.01828363],"study_design_scores_gemma":[0.08562198,0.009461069,0.8222505,0.00006297408,0.003990253,0.0001242706,0.0005881599,0.007412325,0.004156433,0.0007222015,0.06329658,0.002313211],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954424,0.001233544,0.0005481383,0.0007110236,0.0001315399,0.001040897,0.00002792986,0.00008226606,0.0007822958],"genre_scores_gemma":[0.9619716,0.01183455,0.01278281,0.0001811912,0.001497398,0.0001063041,0.0002898728,0.00006454056,0.01127168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1440915,"threshold_uncertainty_score":0.8640249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02531562710539356,"score_gpt":0.3100084937258335,"score_spread":0.28469286662044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}