{"id":"W2168300179","doi":"10.1093/hmg/ddu139","title":"Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age","year":2014,"lang":"en","type":"review","venue":"Human Molecular Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":271,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"FP7 Health; Interreg; National Institute of Diabetes and Digestive and Kidney Diseases; Danmarks Frie Forskningsfond; National Human Genome Research Institute; Danmarks Grundforskningsfond; National Institute of Mental Health; Danish Agency for Science and Higher Education; Tartu Ülikool; Medical Research Council; Forsknings- og Innovationsstyrelsen; Directorate for Biological Sciences; National Institutes of Health; European Social Fund; Tays; Egmont Fonden; U.S. Public Health Service; Centre for Medical Systems Biology; Regione Autonoma della Sardegna; Università della Calabria; Vetenskapsrådet; NIHR Newcastle Biomedical Research Centre; Norwegian Biodiversity Information Centre; Exzellenzclusters Entzündungsforschung; Stiftelsen för Strategisk Forskning; Vrije Universiteit Amsterdam; European Commission; Wellcome Trust; Eesti Teadusfondi; ZonMw; Biotechnology and Biological Sciences Research Council; AXA Research Fund; Institut National de la Recherche Agronomique; Institut National de la Santé et de la Recherche Médicale; Augustinus Fonden; Helsefonden; National Institute on Aging; National Research Foundation; National Institute for Health and Care Research; Avera Institute for Human Genetics; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; European Science Foundation; European Regional Development Fund; King's College London; Network for Studies on Pensions, Aging and Retirement; Bristol-Myers Squibb; March of Dimes Foundation","keywords":"Biology; Longevity; Locus (genetics); Genetics; Genome-wide association study; Genetic association; Computational biology; Evolutionary biology; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005336299,0.001271737,0.003092375,0.001641316,0.0007308847,0.002033263,0.0009803721,0.001414319,0.001732995],"category_scores_gemma":[0.008361897,0.0005821142,0.009145882,0.002979062,0.0004823396,0.0005981361,0.001011119,0.001400695,0.0002168513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004714839,"about_ca_system_score_gemma":0.0005260868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005345033,"about_ca_topic_score_gemma":0.008503504,"domain_scores_codex":[0.9963882,0.001474443,0.0004457459,0.001169012,0.0002724697,0.000250089],"domain_scores_gemma":[0.9947524,0.002888484,0.0008835254,0.0009122781,0.0003377126,0.0002254702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.007023343,0.00005401739,0.5840763,0.003185551,0.3750012,0.0008191356,0.0001425142,0.001479324,0.005324555,0.0003833456,0.001842847,0.02066786],"study_design_scores_gemma":[0.000590722,0.0007140558,0.5978423,0.0006551911,0.3919035,0.0009221988,0.000124496,0.002463038,0.001038376,0.001080906,0.002620839,0.00004428978],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7335825,0.2511394,0.007910225,0.001393814,0.0004602979,0.0000507301,0.003637378,0.0003634824,0.001462179],"genre_scores_gemma":[0.9887664,0.008505639,0.001346125,0.0002505878,0.000115665,0.00002475329,0.000777042,0.00003632275,0.0001775499],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.005345033,"threshold_uncertainty_score":0.02822137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08266054895733739,"score_gpt":0.351240514185834,"score_spread":0.2685799652284966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}