{"id":"W2168357345","doi":"10.1001/jama.2015.4668","title":"Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia","year":2015,"lang":"en","type":"review","venue":"JAMA","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":1635,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; Janssen Pharmaceuticals; National Institute of Biomedical Imaging and Bioengineering; National Institute on Aging; Krajowy Naukowy Osrodek Wiodacy; Sahlgrenska Akademin; National Health and Medical Research Council; Medical Research Council; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; University of California, San Diego; Genentech; Chinese University of Hong Kong; National Institutes of Health; Vlaamse regering; National Research Centre; Academy of Finland; Servier; Innovative Medicines Initiative; Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu; Indian Council of Medical Research; Rheinische Friedrich-Wilhelms-Universität Bonn; Universität zu Köln; Sundhed og Sygdom, Det Frie Forskningsråd; Région Normandie; Universitatea de Medicină şi Farmacie \"Carol Davila\" Bucureşti; Fondation pour la Recherche sur Alzheimer; Radboud Universitair Medisch Centrum; Center for Translational Molecular Medicine; Eli Lilly and Company; Universidade de Lisboa; Merz Pharmaceuticals; Göteborgs Universitet; European Federation of Pharmaceutical Industries and Associations; Bayer HealthCare; Institut National de la Santé et de la Recherche Médicale; H. Lundbeck A/S; Université Pierre et Marie Curie; Universidade de Coimbra; Turun Yliopisto; Deutsches Zentrum für Neurodegenerative Erkrankungen; Belgian Federal Science Policy Office; Rigshospitalet; National and Kapodistrian University of Athens; Eisai; Leids Universitair Medisch Centrum; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Lunds Universitet; Fonds Wetenschappelijk Onderzoek; Dementia Collaborative Research Centres, Australia; F. Hoffmann-La Roche; Université de Genève; Vrije Universiteit Amsterdam; Radboud Universiteit; Universität Heidelberg; Universiteit van Amsterdam; York University; Universiteit Leiden; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Technische Universität München; Imperial College London; Gentofte Hospital; Deutsche Forschungsgemeinschaft; U.S. Department of Defense; Samsung; Commonwealth Scientific and Industrial Research Organisation; Ministero della Salute; Janssen Research and Development; AstraZeneca; Canadian Institutes of Health Research; European Commission; Lui Che Woo Institute of Innovative Medicine; Aristotle University of Thessaloniki; ZonMw; IXICO; Turun Yliopistollinen Keskussairaala; Postgraduate Institute of Medical Education and Research, Chandigarh; Instituto de Investigación Marqués de Valdecilla; Avid Radiopharmaceuticals; Pfizer; EU Joint Programme – Neurodegenerative Disease Research; Sorbonne Université; Universiteit Antwerpen; Northern California Institute for Research and Education; Alzheimer's Association; Science and Industry Endowment Fund; Università degli Studi di Perugia; European Regional Development Fund; Seoul National University; KU Leuven; University of Pittsburgh; University of Pennsylvania; Agence Nationale de la Recherche; Biogen; BioClinica; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Itä-Suomen Yliopisto; Edith Cowan University; Bundesministerium für Bildung und Forschung; Medpace; Sungkyunkwan University; Emory University; Instituto de Salud Carlos III; Synarc; Foundation for the National Institutes of Health; University of Southern California; GlaxoSmithKline; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Lundbeckfonden; AXA Research Fund; Meso Scale Diagnostics; Menzies Centre for Australian Studies, King's College London, University of London; Thomas Jefferson University; National Science Foundation","keywords":"Medicine; Dementia; Amyloid (mycology); Pathology; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01706718,0.001140469,0.005003896,0.004182516,0.000329868,0.001891516,0.00112806,0.001154992,0.001453506],"category_scores_gemma":[0.04003402,0.0008366438,0.01317924,0.004079928,0.0006225104,0.001096432,0.0009475649,0.001063178,0.0001301646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006180374,"about_ca_system_score_gemma":0.0007541063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002695445,"about_ca_topic_score_gemma":0.003684011,"domain_scores_codex":[0.9865528,0.006256206,0.003676636,0.002069884,0.001268495,0.0001760647],"domain_scores_gemma":[0.9693426,0.01898785,0.008602892,0.001495971,0.001384237,0.000186405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"systematic_review","study_design_scores_codex":[0.005307882,0.00004471164,0.2500858,0.1277539,0.5900671,0.0003074605,0.0002916295,0.0009284541,0.0005683418,0.0003163122,0.001597343,0.02273098],"study_design_scores_gemma":[0.001764827,0.0008169592,0.2298143,0.02962344,0.7292745,0.00110568,0.0002787061,0.0007995572,0.0006193395,0.00165549,0.004159766,0.00008744068],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1017367,0.8882602,0.002548323,0.0006805673,0.000318828,0.0003518411,0.00483005,0.00005769664,0.001215697],"genre_scores_gemma":[0.9008293,0.09093158,0.003512581,0.0006971977,0.0002563907,0.0009637403,0.002534632,0.00002440709,0.0002501213],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01706718,"threshold_uncertainty_score":0.09026092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05649265313738155,"score_gpt":0.3834325075835085,"score_spread":0.3269398544461269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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