{"id":"W2168360225","doi":"10.1002/em.20540","title":"Induction of <i>lacZ</i> mutations in Muta™Mouse primary hepatocytes","year":2009,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Natural Sciences and Engineering Research Council of Canada; Health Canada","keywords":"Mutagen; Mutant; Molecular biology; Hepatocyte; Mutation frequency; Biology; In vitro; 2-Acetylaminofluorene; Biochemistry; Chemistry; Carcinogen; Gene; Microsome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003385394,0.0004496773,0.0003600473,0.0002475411,0.0001748815,0.0003001541,0.0002892077,0.0002259379,0.001354743],"category_scores_gemma":[0.0001849363,0.0001738854,0.0003626456,0.0001643857,0.0002148207,0.000132174,0.0002830947,0.0006000509,0.0007336602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002344459,"about_ca_system_score_gemma":0.000189716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000939681,"about_ca_topic_score_gemma":0.001679169,"domain_scores_codex":[0.9996259,0.00006432341,0.0000468382,0.00007278586,0.0001404742,0.00004963877],"domain_scores_gemma":[0.9997203,0.00007500243,0.00005397191,0.00005440456,0.00005296305,0.00004334855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001612233,0.0000075969,0.00006664047,0.00001012718,0.000001563197,0.00002048221,0.000004282142,0.00001341478,0.9996025,0.00002218483,0.0000108508,0.0002242971],"study_design_scores_gemma":[0.00000352269,0.0001335035,0.001201559,0.00000116234,0.000005823408,0.00008873259,0.000006108032,0.0001724518,0.9977883,0.000009919941,0.0005871484,0.000001776985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9553566,0.0009853457,0.03745089,0.0001448121,0.0001098539,0.0002332767,0.001651716,0.0005149259,0.003552557],"genre_scores_gemma":[0.9696048,0.0009681405,0.01923291,0.00008919035,0.00003126966,0.0002121907,0.002211146,0.00008941783,0.007560772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001354743,"threshold_uncertainty_score":0.004532099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00407311115225375,"score_gpt":0.2013598963518398,"score_spread":0.197286785199586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}