{"id":"W2168360225","doi":"10.1002/em.20540","title":"Induction of <i>lacZ</i> mutations in Muta™Mouse primary hepatocytes","year":2009,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Natural Sciences and Engineering Research Council of Canada; Health Canada","keywords":"Mutagen; Mutant; Molecular biology; Hepatocyte; Mutation frequency; Biology; In vitro; 2-Acetylaminofluorene; Biochemistry; Chemistry; Carcinogen; Gene; Microsome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007284678,0.0001336863,0.0001383859,0.00005756072,0.00004004015,0.000008143475,0.00006428959,0.00009042973,0.00001663082],"category_scores_gemma":[0.000003730605,0.0001421861,0.00007170266,0.00004572054,0.00007787212,0.000005642184,0.00005649795,0.0000473392,0.000003104158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002940101,"about_ca_system_score_gemma":0.00001620828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001947723,"about_ca_topic_score_gemma":0.000006956512,"domain_scores_codex":[0.9992164,0.00004142771,0.0001905404,0.0002770489,0.0001237514,0.0001508054],"domain_scores_gemma":[0.9996927,0.00000323788,0.00005742318,0.0001845861,0.000004146393,0.00005785695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003412524,0.0001774528,0.005366985,0.000008465118,0.00001817212,0.00001117713,0.00005621159,0.0001054667,0.987244,0.00002110663,0.00001714544,0.006939745],"study_design_scores_gemma":[0.0004609525,0.0002581532,0.1110557,0.000004514618,0.00002059782,0.00001922886,0.0001192271,0.00001401476,0.8871384,0.000050931,0.0007090946,0.0001492109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977196,0.001223517,0.0004881927,0.00008748671,0.0000211514,0.0001961861,0.00003561946,0.000004832924,0.0002233658],"genre_scores_gemma":[0.9980406,0.0004271457,0.0007274079,0.000421388,0.00002253489,0.00001458191,0.0002279213,0.00001221721,0.000106238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1056887,"threshold_uncertainty_score":0.5798181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00407311115225375,"score_gpt":0.2013598963518398,"score_spread":0.197286785199586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}