{"id":"W2168361625","doi":"10.1016/j.bmcl.2014.05.021","title":"Synthesis and evaluation of 18F-labeled tertiary benzenesulfonamides for imaging carbonic anhydrase IX expression in tumours with positron emission tomography","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Positron emission tomography; In vivo; Carbonic anhydrase; Ex vivo; Enzyme; In vitro; Biochemistry; Nuclear medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000549707,0.0004940435,0.0003999126,0.000256991,0.0002235201,0.000272692,0.0005121187,0.0004910431,0.001204138],"category_scores_gemma":[0.0003871274,0.0002613338,0.0002781301,0.0002798415,0.0002233305,0.0002952931,0.0001985506,0.0004043592,0.0005411261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000751764,"about_ca_system_score_gemma":0.0005375625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001791765,"about_ca_topic_score_gemma":0.002551249,"domain_scores_codex":[0.9998322,0.00004561571,0.00001376919,0.00002362933,0.00003450213,0.00005034975],"domain_scores_gemma":[0.9998154,0.00002904621,0.00004447108,0.00002360094,0.00004022373,0.00004734183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004877191,0.0001204901,0.0002095758,0.0001695635,0.00002622148,0.000311287,0.0001115121,0.001858688,0.9877868,0.0008156931,0.0002778842,0.007824442],"study_design_scores_gemma":[0.00008519599,0.001089003,0.0005864145,0.000008217034,0.00003050595,0.0002559655,0.00001671495,0.001169524,0.9914743,0.00004491282,0.005226411,0.00001287944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9554589,0.005381007,0.02962548,0.0002921376,0.00008224873,0.0006421581,0.0009019169,0.000236827,0.007379295],"genre_scores_gemma":[0.976199,0.003366279,0.0150696,0.000076109,0.0000232791,0.0001940585,0.0009336842,0.00007011823,0.004067913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001791765,"threshold_uncertainty_score":0.005454481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005377274377020196,"score_gpt":0.2197022782225751,"score_spread":0.2143250038455549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}