{"id":"W2168418835","doi":"10.2337/db14-0508","title":"Methotrexate Promotes Glucose Uptake and Lipid Oxidation in Skeletal Muscle via AMPK Activation","year":2014,"lang":"en","type":"article","venue":"Diabetes","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novo Nordisk Fonden; Javna Agencija za Raziskovalno Dejavnost RS; Novo Nordisk; Karolinska Institutet; Vetenskapsrådet; Cancer Research UK; Hospital for Sick Children; Wellcome Trust","keywords":"AMPK; AMP-activated protein kinase; Skeletal muscle; Glucose uptake; Chemistry; Endocrinology; Internal medicine; Activator (genetics); Myogenesis; Biochemistry; Biology; Insulin; Protein kinase A; Phosphorylation; Medicine; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008206897,0.0003175024,0.0002163067,0.0001924219,0.0001460351,0.0002505446,0.0001160203,0.0002180002,0.001180438],"category_scores_gemma":[0.00007645235,0.0001232107,0.0002364267,0.0001733664,0.0001734498,0.0001529618,0.000145189,0.000352399,0.0003029139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002972256,"about_ca_system_score_gemma":0.0001179528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005245754,"about_ca_topic_score_gemma":0.001122784,"domain_scores_codex":[0.9999007,0.00002551187,0.00001119019,0.00002677597,0.00002003844,0.00001582422],"domain_scores_gemma":[0.999953,0.000007299499,0.00002183336,0.000004689284,0.000005084125,0.000008067197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000189088,0.00001558367,0.0002119108,0.00005183414,0.000007297572,0.00005746705,0.000006112405,0.00002706479,0.9979343,0.00006322871,0.00003987826,0.00139625],"study_design_scores_gemma":[0.00005774876,0.000705756,0.01790288,0.00001952802,0.00005103265,0.000450069,0.0000356126,0.0006947453,0.9756623,0.00007637149,0.004337046,0.000006759809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766409,0.01555599,0.003618137,0.000424462,0.0001085145,0.00003256632,0.0003602823,0.0001229923,0.003136096],"genre_scores_gemma":[0.990728,0.004791911,0.001849737,0.0001055331,0.00002954946,0.00002667128,0.0002443228,0.00001191654,0.002212361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001180438,"threshold_uncertainty_score":0.003948987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007587289461803846,"score_gpt":0.2310839165203934,"score_spread":0.2234966270585896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}