{"id":"W2168418835","doi":"10.2337/db14-0508","title":"Methotrexate Promotes Glucose Uptake and Lipid Oxidation in Skeletal Muscle via AMPK Activation","year":2014,"lang":"en","type":"article","venue":"Diabetes","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novo Nordisk Fonden; Javna Agencija za Raziskovalno Dejavnost RS; Novo Nordisk; Karolinska Institutet; Vetenskapsrådet; Cancer Research UK; Hospital for Sick Children; Wellcome Trust","keywords":"AMPK; AMP-activated protein kinase; Skeletal muscle; Glucose uptake; Chemistry; Endocrinology; Internal medicine; Activator (genetics); Myogenesis; Biochemistry; Biology; Insulin; Protein kinase A; Phosphorylation; Medicine; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003387592,0.0001374738,0.0001574017,0.00005969359,0.00004186942,0.00003298725,0.00008324217,0.0001151345,0.000025004],"category_scores_gemma":[0.000190764,0.0001321305,0.00004033712,0.00009682882,0.00004789832,0.00001650773,0.00004566634,0.00006644048,0.000007628755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007878874,"about_ca_system_score_gemma":0.0000148352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001308559,"about_ca_topic_score_gemma":0.00001653949,"domain_scores_codex":[0.9991141,0.00008617044,0.0001685327,0.0003058066,0.00008988122,0.0002354955],"domain_scores_gemma":[0.9995985,0.00002292367,0.00007973434,0.0002024594,0.00004753402,0.00004885405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000002452527,0.00002458014,0.001919433,0.00002099592,0.00000923942,2.966813e-8,0.00002519158,0.00000377637,0.634515,0.00004716017,0.00004570343,0.3633864],"study_design_scores_gemma":[0.0004181588,0.00008144922,0.04212824,0.00001643984,0.00001181432,1.040501e-7,0.00001186923,0.0004721739,0.8084086,0.0004967291,0.1477856,0.0001688394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889315,0.009902561,0.0005973007,0.00003649246,0.0001195815,0.0001505346,0.000003855126,0.00001442698,0.0002437976],"genre_scores_gemma":[0.9968887,0.001392811,0.000664949,0.0003840274,0.0003720387,0.00005005953,0.0001934504,0.00002064735,0.0000333459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3632175,"threshold_uncertainty_score":0.5388126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007587289461803846,"score_gpt":0.2310839165203934,"score_spread":0.2234966270585896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}