{"id":"W2168432020","doi":"10.1074/jbc.m209397200","title":"Non-nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":192,"is_retracted":false,"has_abstract":true,"ca_institutions":"BioPhage Pharma (Canada); Canadian Institutes of Health Research; University of Alberta","funders":"","keywords":"NS5B; Allosteric regulation; Binding site; Chemistry; Stereochemistry; Active site; Polymerase; RNA polymerase; Nucleoside triphosphate; Hydrogen bond; Nucleoside; Biochemistry; Nucleotide; RNA; Enzyme; Molecule; Hepacivirus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005258438,0.0001896018,0.0004534167,0.0001020367,0.00005914121,0.00003213369,0.0001794653,0.0002629795,0.0007567079],"category_scores_gemma":[0.0009857728,0.000130789,0.0001859735,0.0003158222,0.00009433033,0.00006402983,0.00004744408,0.0006790899,0.0001095952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001455574,"about_ca_system_score_gemma":0.0001589078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001349573,"about_ca_topic_score_gemma":0.00000199036,"domain_scores_codex":[0.9982594,0.00008168374,0.0005420005,0.0002631529,0.0004590846,0.0003947057],"domain_scores_gemma":[0.9983745,0.00009688473,0.0001727556,0.0002729915,0.0001875649,0.000895258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004612326,0.0004005824,0.05943166,0.00002880386,0.00004333567,0.0009498728,0.00004507698,0.000005737426,0.9313622,0.000001924426,0.001517218,0.005752366],"study_design_scores_gemma":[0.001353385,0.002758771,0.02855196,0.00018203,0.00002600325,0.000376898,0.00008140408,0.0000114861,0.9485629,0.00002031475,0.01785861,0.0002162086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922526,0.0001121219,0.00001828175,0.0008000734,0.00007954145,0.0001187275,0.00001666799,0.00001366051,0.006588256],"genre_scores_gemma":[0.9970963,0.00008959236,0.0005899547,0.001470471,0.0004735628,0.000003295997,0.00001495252,0.00001757508,0.0002442877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0308797,"threshold_uncertainty_score":0.8285421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04337628447423647,"score_gpt":0.3277223665346248,"score_spread":0.2843460820603884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}