{"id":"W2168432020","doi":"10.1074/jbc.m209397200","title":"Non-nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":192,"is_retracted":false,"has_abstract":true,"ca_institutions":"BioPhage Pharma (Canada); Canadian Institutes of Health Research; University of Alberta","funders":"","keywords":"NS5B; Allosteric regulation; Binding site; Chemistry; Stereochemistry; Active site; Polymerase; RNA polymerase; Nucleoside triphosphate; Hydrogen bond; Nucleoside; Biochemistry; Nucleotide; RNA; Enzyme; Molecule; Hepacivirus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001931388,0.0003270488,0.0006372717,0.0001608733,0.000287007,0.0005263677,0.0004579105,0.0003682711,0.001465739],"category_scores_gemma":[0.00040025,0.0002775818,0.0002604793,0.000129108,0.0003377187,0.0001701984,0.0002114412,0.0005651954,0.0004456143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008385557,"about_ca_system_score_gemma":0.0003577428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001994154,"about_ca_topic_score_gemma":0.00339772,"domain_scores_codex":[0.9997352,0.00004909339,0.00001284566,0.00003451965,0.0001276959,0.00004072978],"domain_scores_gemma":[0.9998432,0.00005897055,0.00003429803,0.000008473649,0.00001673449,0.00003825579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001039495,0.0002146975,0.003170802,0.0002539474,0.00008717046,0.0007400076,0.0001414808,0.006128668,0.9760118,0.001085051,0.0006596745,0.0104674],"study_design_scores_gemma":[0.0009439493,0.00170268,0.01942241,0.00009347816,0.0001895116,0.002262284,0.0001889192,0.04317418,0.9089096,0.0005591333,0.02246234,0.00009153098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872945,0.004594713,0.00240891,0.0001475672,0.00004894803,0.00003578492,0.0001045385,0.00009636238,0.005268558],"genre_scores_gemma":[0.9947705,0.001537307,0.001717633,0.0001405767,0.0000171196,0.00002089501,0.000255644,0.00001732299,0.001523066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001994154,"threshold_uncertainty_score":0.006084204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04337628447423647,"score_gpt":0.3277223665346248,"score_spread":0.2843460820603884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}