{"id":"W2168465652","doi":"10.1128/jvi.01727-09","title":"Herpes Simplex Virus VP16, but Not ICP0, Is Required To Reduce Histone Occupancy and Enhance Histone Acetylation on Viral Genomes in U2OS Osteosarcoma Cells","year":2009,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Fondation pour la Recherche Médicale","keywords":"Biology; Histone; Chromatin; Chromatin immunoprecipitation; Herpes simplex virus; Histone H2A; Viral replication; Histone acetyltransferase; Molecular biology; Cell biology; Virus; Virology; DNA; Gene; Gene expression; Genetics; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001935002,0.0003901781,0.0004281766,0.0002847994,0.0002489848,0.0004637241,0.0003146113,0.0002327259,0.001272791],"category_scores_gemma":[0.0002181356,0.0002840932,0.0003554844,0.0002549634,0.0003720575,0.0002669608,0.0003271249,0.0003987091,0.0005540758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004470895,"about_ca_system_score_gemma":0.0003500358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0024738,"about_ca_topic_score_gemma":0.00245647,"domain_scores_codex":[0.9997613,0.00002666692,0.00003873776,0.00004519256,0.00007717756,0.00005084137],"domain_scores_gemma":[0.9996755,0.00005618473,0.00007562818,0.00006330353,0.00003037629,0.00009890422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003597872,0.00001266921,0.0001527151,0.00001023123,0.000002033409,0.00002793348,0.00001407618,0.00001939848,0.9994118,0.0000493558,0.00001524219,0.0002485649],"study_design_scores_gemma":[0.000009619628,0.0001498885,0.006071313,0.000002912445,0.000005889869,0.0001416944,0.00004234498,0.000483074,0.991998,0.00003766621,0.001053101,0.000004569413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956469,0.0006711009,0.002260489,0.00004187648,0.000024315,0.00001989957,0.0004375805,0.0001171209,0.0007807683],"genre_scores_gemma":[0.9919133,0.0005138051,0.003742468,0.00003822729,0.00001045034,0.00004012881,0.00103205,0.00006184325,0.002647791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0024738,"threshold_uncertainty_score":0.004918754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02220715424811299,"score_gpt":0.3535160602998337,"score_spread":0.3313089060517208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}