{"id":"W2168472426","doi":"10.1186/2110-5820-2-15","title":"Design, conduct, and analysis of a multicenter, pharmacogenomic, biomarker study in matched patients with severe sepsis treated with or without drotrecogin Alfa (activated)","year":2012,"lang":"en","type":"article","venue":"Annals of Intensive Care","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"University of California, San Diego; Simon Fraser University; National Institute for Health and Care Research; American Heart Association","keywords":"Medicine; Drotrecogin alfa; Internal medicine; Propensity score matching; Anesthesiology; Sepsis; Multicenter trial; Procalcitonin; Biomarker; Intensive care medicine; Randomized controlled trial; Septic shock; Multicenter study; Severe sepsis; Anesthesia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01238903,0.001543878,0.001820483,0.0008036431,0.001541628,0.0009689018,0.001159764,0.001519598,0.002555996],"category_scores_gemma":[0.0097187,0.001016518,0.001656495,0.0008841985,0.001761961,0.000864569,0.001042408,0.0009396028,0.0005553746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001262975,"about_ca_system_score_gemma":0.00311967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001133947,"about_ca_topic_score_gemma":0.001061116,"domain_scores_codex":[0.9904727,0.006087532,0.0006060884,0.00162591,0.0006247275,0.0005831084],"domain_scores_gemma":[0.994181,0.0009924558,0.001593244,0.001477188,0.0005813005,0.001174881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5429432,0.03685154,0.3774648,0.0005278009,0.002743659,0.0009269366,0.0007962498,0.001342657,0.01647344,0.0009162358,0.001229067,0.01778436],"study_design_scores_gemma":[0.1936566,0.4336165,0.3549715,0.00008814331,0.002418774,0.0009805036,0.0006704726,0.002558667,0.005398639,0.001056855,0.004445049,0.0001383191],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852035,0.0004723139,0.002480866,0.0001808151,0.0001281312,0.01028678,0.0006711052,0.00001928687,0.0005571027],"genre_scores_gemma":[0.9806842,0.0001095035,0.005026063,0.0007389229,0.0002631662,0.01210071,0.0006991006,0.000009908091,0.0003684504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01238903,"threshold_uncertainty_score":0.06552029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2059413156564779,"score_gpt":0.4018055535208436,"score_spread":0.1958642378643657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}